Neoadjuvant combination immunotherapy in MSI/dMMR colorectal cancer

被引：0
|
作者：
Suarez-Carmona, Meggy [1 ,2 ]
Halama, Niels [1 ,2 ,3 ,4 ]
机构：
[1] German Canc Res Ctr, Dept Canc Immunol & Canc Immunotherapy, Heidelberg, Germany
[2] Helmholtz Inst Translat Oncol HI TRON, Mainz, Germany
[3] Johannes Gutenberg Univ Mainz, Univ Canc Ctr Mainz UCT Mainz, Univ Med Ctr, Mainz, Germany
[4] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Dept Hematol Med Oncol & Pneumol, Mainz, Germany
来源：
TRENDS IN CANCER | 2024年 / 10卷 / 12期
关键词：
MISMATCH REPAIR-DEFICIENT; NIVOLUMAB;
D O I：
10.1016/j.trecan.2024.10.006
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Neoadjuvant immune checkpoint inhibition (ICI) is a new approach to treat patients with colorectal cancer (CRC). The effects of combined neoadjuvant ICI in locally advanced, DNA mismatch repair (dMMR)-deficient/microsatellite instable (MSI) CRC were recently reported by de Gooyer et al. from the NICHE-3 trial. Further studies will determine whether these impressive pathological responses lead to long-term clinical benefit.
引用
收藏
页码：1093 / 1094
页数：2
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