First results of nivolumab (NIVO) plus ipilimumab (IPI) vs NIVO monotherapy for microsatellite instability-high/mismatch repair-deficient (MSI-H/dMMR) metastatic colorectal cancer (mCRC) from CheckMate 8HW.

被引：0

作者：

Andre, Thierry

Elez, Elena

Lenz, Heinz-Josef

Jensen, Lars Henrik

Touchefeu, Yann

Van Cutsem, Eric

Garcia-Carbonero, Rocio

Tougeron, David

Mendez, Guillermo

Schenker, Michael

de la Fouchardiere, Christelle

Limon, Maria Luisa

Yoshino, Takayuki

Li, Jin

Aubin, Francine

Cela, Elvis

Chen, Tian

Lei, Ming

Jin, Lixian

Lonardi, Sara

机构：

[1] Sorbonne Univ, Paris, France

[2] Hop St Antoine, Assistance Publ Hop Paris, Paris, France

[3] Vall Hebron Univ Hosp, Barcelona, Spain

[4] Inst Oncol VHIO, Barcelona, Spain

[5] Univ Southern Calif, Norris Comprehens Canc Ctr, Los Angeles, CA USA

[6] Univ Hosp Southern Denmark, Vejle Hosp, Vejle, Denmark

[7] Ctr Hosp Univ Nantes, Nantes, France

[8] Univ Penn, Philadelphia, PA USA

[9] UCM, Hosp Univ 12 Octubre Imas12, Madrid, Spain

[10] Ctr Hosp Univ Poitiers Site Miletrie, Poitiers, France

[11] Hosp Univ Fdn Favaloro, Buenos Aires, Argentina

[12] Centrul Oncol Sf Nectarie, Craiova, Romania

[13] Univ Med & Pharm, Craiova, Romania

[14] Ctr Leon Berard, Lyon, France

[15] Hosp Univ Virgendel Rocio, Seville, Spain

[16] Natl Canc Ctr Hosp East Kashiwa, Chiba, Japan

[17] Shanghai East Hosp, Shanghai, Peoples R China

[18] Ctr Hosp Univ Montreal, Montreal, PQ, Canada

[19] Bristol Myers Squibb, Princeton, NJ USA

来源：

JOURNAL OF CLINICAL ONCOLOGY | 2025年 / 43卷 / 4_SUPPL期

关键词：

D O I：

10.1200/JCO.2025.43.4_suppl.LBA143

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

LBA143

引用

页码：LBA143 / LBA143

页数：1

共 50 条

[21] Subgroup analyses of patients (pts) with microsatellite instability-high/mismatch repair-deficient (MSI-H/dMMR) metastatic colorectal cancer (mCRC) treated with nivolumab (NIVO) plus low-dose ipilimumab (IPI) as first-line (1L) therapy:Two-year clinical update.
Lenz, Heinz-Josef
Lonardi, Sara
Zagonel, Vittorina
Van Cutsem, Eric
Limon, Luisa M.
Wong, Ka Yeung Mark
Hendlisz, Alain
Aglietta, Massimo
Garcia-Alfonso, Pilar
Neyns, Bart
Luppi, Gabriele
Cardin, Dana Backlund
Dragovich, Tomislav
Shah, Usman
Yang Jing
Memaj, Arteid
Overman, Michael J.
JOURNAL OF CLINICAL ONCOLOGY, 2021, 39 (03)
[22] On pembrolizumab (Keytruda) in microsatellite instability-high/mismatch repair deficient (MSI-h/MMRd) metastatic colorectal cancer (mCRC)
Bekaii-Saab, Tanios S.
ONCOLOGY-NEW YORK, 2021, 35 (07): : 380 - 380
[23] Durable Clinical Benefit With Nivolumab Plus Ipilimumab in DNA Mismatch Repair-Deficient/Microsatellite Instability-High Metastatic Colorectal Cancer
Overman, Michael J.
Lonardi, Sara
Wong, Ka Yeung Mark
Lenz, Heinz-Josef
Gelsomino, Fabio
Aglietta, Massimo
Morse, Michael A.
Van Cutsem, Eric
McDermott, Ray
Hill, Andrew
Sawyer, Michael B.
Hendlisz, Alain
Neyns, Bart
Svrcek, Magali
Moss, Rebecca A.
Ledeine, Jean-Marie
Cao, Z. Alexander
Kamble, Shital
Kopetz, Scott
Andre, Thierry
JOURNAL OF CLINICAL ONCOLOGY, 2018, 36 (08) : 773 - +
[24] RECIST and iRECIST criteria for the evaluation of nivolumab plus ipilimumab combination in patients (pts) with microsatellite instability-high/mismatch repair-deficient (MSI/dMMR) metastatic colorectal cancer (mCRC): Results of the GERCOR NIPICOL phase II study
Cohen, Romain
Bennouna, Jaafar
Henriques, Julie
Tournigand, Christophe
De La Fouchardiere, Christelle
Tougeron, David
Borg, Christophe
Mazard, Thibault
Chibaudel, Benoist
Garcia-Larnicol, Marie-Line
Svrcek, Magali
Vernerey, Dewi
Menu, Yves
Andre, Thierry
JOURNAL OF CLINICAL ONCOLOGY, 2020, 38 (04)
[25] Exploratory Analysis of Janus Kinase 1 (JAK1) Loss-of-Function (LoF) Mutations in Patients with DNA Mismatch Repair-Deficient/Microsatellite Instability-High (dMMR/MSI-H) Metastatic Colorectal Cancer (mCRC) Treated with Nivolumab plus Ipilimumab in CheckMate-142
Kopetz, S.
Andre, T.
Overman, M. J.
Zagonel, V.
Lonardi, S.
Aglietta, M.
Gelsomino, F.
McDermott, R.
Wong, K. Y. M.
Hendlisz, A.
Alfonso, P. G.
Lenz, H. J.
Walsh, A.
Moss, R. A.
Greenawalt, D.
Cao, Z. A.
JOURNAL OF MOLECULAR DIAGNOSTICS, 2018, 20 (03): : S3 - S3
[26] Exploratory analysis of Janus kinase 1 (JAK1) loss-of-function (LoF) mutations in patients with DNA mismatch repair-deficient/microsatellite instability-high (dMMR/MSI-H) metastatic colorectal cancer (mCRC) treated with nivolumab plus ipilimumab in CheckMate-142
Kopetz, Scott
Andre, Theirry
Overman, Michael J.
Zagonel, Vittorina
Lonardi, Sara
Aglietta, Massimo
Gelsomino, Fabio
McDermott, Ray
Wong, Ka Yeung Mark
Hendlisz, Alain
Garcia Alfonso, Pilar
Lenz, Heinz-Josef
Walsh, Alice
Moss, Rebecca A.
Greenawalt, Danielle
Cao, Z. Alexander
CANCER RESEARCH, 2018, 78 (13)
[27] First-Line Nivolumab Plus Low-Dose Ipilimumab for Microsatellite Instability-High/Mismatch Repair-Deficient Metastatic Colorectal Cancer: The Phase II CheckMate 142 Study
Lenz, Heinz-Josef
Van Cutsem, Eric
Limon, Maria Luisa
Wong, Ka Yeung Mark
Hendlisz, Alain
Aglietta, Massimo
Garcia-Alfonso, Pilar
Neyns, Bart
Luppi, Gabriele
Cardin, Dana B.
Dragovich, Tomislav
Shah, Usman
Abdullaev, Sandzhar
Gricar, Joseph
Ledeine, Jean-Marie
Overman, Michael James
Lonardi, Sara
JOURNAL OF CLINICAL ONCOLOGY, 2022, 40 (02) : 161 - +
[28] Neoadjuvant nivolumab plus ipilimumab in microsatellite instability-high (MSI-H)/deficient mismatch repair (dMMR) rectal tumors: ECOG-ACRIN EA2201
Ciombor, K. K.
Hong, S.
Eng, C.
Yao, X.
You, N.
Das, P.
Chakravarthy, A.
O'Dwyer, P. J.
ANNALS OF ONCOLOGY, 2024, 35 : S104 - S104
[29] Safety of Nivolumab plus Low-Dose Ipilimumab in Previously Treated Microsatellite Instability-High/Mismatch Repair-Deficient Metastatic Colorectal Cancer
Morse, Michael A.
Overman, Michael J.
Hartman, Leighanne
Khoukaz, Taline
Brutcher, Edith
Lenz, Heinz-Josef
Atasoy, Ajlan
Shangguan, Tong
Zhao, Huanyu
El-Rayes, Bassel
ONCOLOGIST, 2019, 24 (11): : 1453 - 1461
[30] Concordance of DNA mismatch repair deficient (dMMR)/microsatellite instability (MSI) assessment by local and central testing in patients with metastatic CRC (mCRC) receiving nivolumab (nivo) in CheckMate 142 study.
Kopetz, Scott
Lonardi, Sara
McDermott, Raymond S.
Aglietta, Massimo
Hendlisz, Alain
Morse, Michael
Leach, Joseph W.
Neyns, Bart
Chan, Emily
Chen, Franklin
Wong, Ka Yeung Mark
Lee, James J.
Garcia-Alfonso, Pilar
Hill, Andrew G.
Lenz, Heinz-Josef
Desai, Jayesh
JOURNAL OF CLINICAL ONCOLOGY, 2017, 35

← 1 2 3 4 5 →