Distance matters : How protein regulators facilitate enhancer-promoter interactions and transcription

被引：0

作者：

Nagano, Masahiro ^{[1
,2
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,4
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]}

Hansen, Anders S. ^{[1
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,4
]}

机构：

[1] MIT, Dept Biol Engn, Cambridge, MA 02139 USA

[2] Broad Inst MIT & Harvard, Gene Regulat Observ, Cambridge, MA 02139 USA

[3] Broad Inst MIT & Harvard, Novo Nordisk Fdn Ctr Genom Mech Dis, Cambridge, MA 02142 USA

[4] Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA

[5] Kyoto Univ, Inst Adv Study Human Biol ASHBi, Yoshida Konoe Cho,Sakyo Ku, Kyoto 6068501, Japan

来源：

CELL GENOMICS | 2025年 / 5卷 / 03期

关键词：

COHESIN; CTCF;

D O I：

10.1016/j.xgen.2025.100817

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cohesin, transcription factors (TFs), and mediator complex components regulate gene expression partly by regulating enhancer-promoter (E-P) communication. A new study combined E-P distance-controlled reporter screens with the inhibition or degradation of regulatory proteins and uncovered a distance-dependent effect across cohesin, TFs, and mediator complex components.

引用

页数：3

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