Phase 1b Study of AMG 193, An MTA-Cooperative PRMT5i, Alone and in Combination with Other Therapies in MTAP-deleted NSCLC

被引：0

作者：

Spira, A. ^{[1
]}

Sacher, A. ^{[2
]}

Paz-Ares Rodriguez, L. ^{[3
]}

Felip, E. ^{[4
]}

Reguart, N. ^{[5
]}

Desar, I. ^{[6
]}

Punekar, S. ^{[7
]}

Dy, G. ^{[8
]}

Fontana, E. ^{[9
]}

Udagawa, H. ^{[10
]}

El Helali, A. ^{[11
]}

Menis, J. ^{[12
]}

Hummel, H. -D. ^{[13
]}

Itsara, A. ^{[14
]}

Eggert, T. ^{[14
]}

Besse, B. ^{[15
]}

机构：

[1] Virginia Canc Specialists, Fairfax, VA USA

[2] Univ Toronto, Princess Margaret Canc Ctr, Toronto, ON, Canada

[3] Hosp Doce Octubre, Madrid, Spain

[4] Vall dHebron Univ Hosp, Barcelona, Spain

[5] Hosp Clin Barcerlona, Barcelona, Spain

[6] Radboud Univ Nijmegen Med Ctr, Nijmegen, Netherlands

[7] NYU Langones Perlutter Hlth, New York, NY USA

[8] Roswell Park Comprehens Ctr Inst, Buffalo, NY USA

[9] Sarah Cannon Res Inst, London, England

[10] Natl Canc Ctr Hosp East Japan, Kashiwa, Chiba, Japan

[11] Queen Mary Hosp, Hong Kong, Peoples R China

[12] Univ Hosp Verona, Verona, Italy

[13] Univ Hosp Wurzburg, Wurzburg, Germany

[14] Amgen Inc, Thousand Oaks, CA USA

[15] Gustave Roussy, Orsay, France

来源：

JOURNAL OF THORACIC ONCOLOGY | 2024年 / 19卷 / 10期

关键词：

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

P3.12D.10

引用

页码：S350 / S350

页数：1

共 32 条

[1] Discovery of AMG 193, an MTA-Cooperative PRMT5 Inhibitor for the Treatment of MTAP-Deleted Cancers
Pettus, Liping H.
Bourbeau, Matthew
Tamayo, Nuria A.
Amegadzie, Albert
Beylkin, Diane
Booker, Shon K.
Butler, John
Frohn, Michael J.
Kaller, Matthew R.
Kohn, Todd
Lanman, Brian A.
Li, Kexue
Liu, Qingyian
Ma, Vu
Medina, Jose
Minatti, Ana E.
Lopez, Patricia
Manoni, Francesco
Pickrell, Alex
Weires, Nicholas
Andersson, Jan
Cowland, Sanne
Glad, Sanne
Sarvary, Ian
Vestergaard, Mikkel
Li, Weikun
Ghimire-Rijal, Sudipa
Mardirossian, Narbe
Mukund, Susmith
Chen, Qing
Lo, Mei-Chu
Ngo, Rachel
Khetan, Jawahar
Madoux, Franck
Sanders, Christiana
Sharma, Pooja
Wang, Paul
Bruenner, Bernd
Mccloud, Stuart
Ponce, Manuel
Soto, Marcus
Wahlstrom, Jan
Xie, Fang
Yang, Yajing
Liu, Siyuan
Tan, Hong
Policheni, Antonia
Caenepeel, Sean
Slemmons, Katherine K.
Belmontes, Brian
JOURNAL OF MEDICINAL CHEMISTRY, 2025,
[2] AMG 193, a Clinical Stage MTA-Cooperative PRMT5 Inhibitor, Drives Antitumor Activity Preclinically and in Patients with MTAP-Deleted Cancers
Belmontes, Brian
Slemmons, Katherine K.
Su, Chun
Liu, Siyuan
Policheni, Antonia N.
Moriguchi, Jodi
Tan, Hong
Xie, Fang
Aiello, Daniel Andrew
Yang, Yajing
Lazaro, Raul
Aeffner, Famke
Rees, Matthew G.
Ronan, Melissa M.
Roth, Jennifer A.
Vestergaard, Mikkel
Cowland, Sanne
Andersson, Jan
Sarvary, Ian
Chen, Qing
Sharma, Pooja
Lopez, Patricia
Tamayo, Nuria
Pettus, Liping H.
Ghimire-Rijal, Sudipa
Mukund, Susmith
Allen, Jennifer R.
Devoss, Jason
Coxon, Angela
Rodon, Jordi
Ghiringhelli, Francois
Penel, Nicolas
Prenen, Hans
Glad, Sanne
Chuang, Chen-Hua
Keyvanjah, Kiana
Townsley, Danielle M.
Butler, John R.
Bourbeau, Matthew P.
Caenepeel, Sean
Hughes, Paul E.
CANCER DISCOVERY, 2025, 15 (01) : 139 - 161
[3] Phase I dose escalation and initial dose expansion results of AMG 193: A MTA-cooperative PRMT5 inhibitor, in patients (pts) with MTAP-deleted solid tumors
Sacher, A. G.
Villalona-Calero, M.
O'Neil, B. H.
Rodon, J.
Doi, T.
Postel-Vinay, S.
Ghiringhelli, F.
Yamamoto, N.
Wahlroos, S.
Villaruz, L.
El-Helali, A.
Fujiwara, Y.
Addeo, A.
Lin, C-C.
Fontana, E.
Chuang, C-H.
Liu, C.
Eggert, T.
Penel, N.
Prenen, H.
ANNALS OF ONCOLOGY, 2024, 35 : S484 - S485
[4] First-in-human study of AMG 193, an MTA-cooperative PRMT5 inhibitor, in patients with MTAP-deleted solid tumors: results from phase I dose exploration5
Rodon, J.
Prenen, H.
Sacher, A.
Villalona-Calero, M.
Penel, N.
El Helali, A.
Rottey, S.
Yamamoto, N.
Ghiringhelli, F.
Goebeler, M. E.
Doi, T.
Postel-Vinay, S.
Lin, C. -c.
Liu, C.
Chuang, C. -h.
Keyvanjah, K.
Eggert, T.
Neil, B. h. o '
ANNALS OF ONCOLOGY, 2024, 35 (12) : 1138 - 1147
[5] Phase 1/2, Dose-expansion Study of AMG 193, an MTAcooperative PRMT5 Inhibitor, In MTAP-deleted NSCLC
Sacher, A.
Addeo, A.
Doi, T.
Chu, Q.
El Helali, A.
Villaruz, L.
Prenen, H.
Vokes, N.
Rodon, J.
Durm, G.
Lebellec, L.
O'Neil, B.
Dy, G.
Eggert, T.
Keyvanjah, K.
Gadgeel, S.
JOURNAL OF THORACIC ONCOLOGY, 2024, 19 (10) : S350 - S351
[6] Discovery of novel MTA-cooperative PRMT5 inhibitors as targeted therapeutics for MTAP-deleted cancers
Bartosik, Anna
Radzimierski, Adam
Bobowska, Aneta
Levenets, Oleksandr
Stachowicz, Agata
Kus, Kamil
Michalik, Kinga
Banaszak, Katarzyna
Madej, Monika
Skoda, Marta
Kozlowska-Tomczyk, Kamila
Tomczyk, Igor
Pyziak, Karolina
Krzemien, Dobroslawa
Gladysz, Miroslawa
Podkalicka, Paulina
Golas, Aniela
Gluza, Karolina
Satala, Grzegorz
Gondela, Andrzej
Sowinska, Marta
Boutard, Nicolas
Chlopek, Agata
Wieckowska, Aleksandra
Szukiel, Daria
Cwiertnia, Grzegorz
Levenets, Iana
Zuchowicz, Karol
Korta-Piatek, Klara
Nowogrodzki, Marcin
Wronowski, Marek
Girardi, Marianna
Swirski, Mateusz
Popika, Oleksandr
Niedziejko-Cwiertnia, Paulina
Cordone, Pierpaolo
Wyrebek, Przemyslaw
Vu, Qu. Nh
Sasmal, Sujit
Sukhomlinova, Svitlana
Miodek, Magdalena
Faber, Jacek
Kowal-Chwast, Anna
Starczak, Roza
Ratajczak, Sanja Novak
Swirska, Agnieszka
Gogola, Dawid
Guzik, Pawel
Swarbrick, Martin
Nowak, Mateusz
CANCER RESEARCH, 2023, 83 (07)
[7] Discovery of novel MTA-cooperative PRMT5 inhibitors as targeted therapeutics for MTAP-deleted cancers
Radzimierski, Adam
Bobowska, Aneta
Stachowicz, Agata
Kus, Kamil
Korlowska-Tomczyk, Kamila
Ludwig-Slomczynska, Agnieszka
Golas, Aniela
Podkalicka, Paulina
Gondela, Andrzej
Boutard, Nicolas
Cwiertnia, Grzegorz
Brzozka, Krzysztof
Bartosik, Anna
Nowak, Mateusz
Pez, Didier
MOLECULAR CANCER THERAPEUTICS, 2023, 22 (12)
[8] Discovery of novel MTA-cooperative PRMT5 inhibitors as targeted therapeutics for MTAP-deleted cancers
Radzimierski, Adam
Bobowska, Aneta
Stachowicz, Agata
Kus, Kamil
Kozlowska-Tomczyk, Kamila
Ludwig-Slomczynska, Agnieszka
Podkalicka-Golda, Paulina
Golas, Aniela
Zukowska, Monika
Lebed, Pavlo
Wyrebek, Przemyslaw
Szukiel, Daria
Stefaniak, Matylda
Popika, Oleksandr
Krzywik, Julia
Sasmal, Sujit
Niedziejko-Cwiertnia, Paulina
Korta-Piatek, Klara
Fijolkowska, Karolina
Wieckowska, Aleksandra
Olszak-Plachta, Marta
Nipunge, Swapnil
Swirski, Mateusz
Wronowski, Marek
Pawlik, Henryk
Quynh Vu
Lagosz-Cwik, Katarzyna
Stoszko, Mateusz
Woroszylo, Szymon
Tomczyk, Igor
Gabor-Worwa, Ewelina
Gaud, Nilesh
Kowal-Chwast, Anna
Gogola, Dawid
Miodek, Magdalena
Starczak, Roza
Dudek, Agata
Faber, Jacek
Winnik, Bozena
Novak-Ratajczak, Sanja
Swirska, Agnieszka
Gluza, Karolina
Guzik, Pawel
Banaszak, Katarzyna
Boutard, Nicolas
Cwiertnia, Grzegorz
Brzozka, Krzysztof
Nowak, Mateusz
Bartosik, Anna
Pez, Didier
CANCER RESEARCH, 2024, 84 (06)
[9] Discovery of novel MTA-cooperative PRMT5 inhibitors as targeted therapeutics for MTAP-deleted cancers
Radzimierski, A.
Bobowska, A.
Stachowicz, A.
Kus, K.
Kozlowska-Tomczyk, K.
Ludwig-Slomczynska, A.
Golas, A.
Zukowska, M.
Cwiertnia, G.
Brzozka, K.
Nowak, M.
Bartosik, A.
Pez, D.
EUROPEAN JOURNAL OF CANCER, 2024, 211 : S14 - S15
[10] Design of a Phase 1 Study of AMG 193, an MTA-Cooperative PRMT5 Inhibitor, in Patients with Advanced MTAP-Null Solid Tumors
Calero, M. Villalona
Patnaik, A.
Maki, R.
O'Neil, B.
Abbruzzese, J.
Dagogo-Jack, I.
Devarakonda, S.
Wahlroos, S.
Lin, C. C.
Fujiwara, Y.
Terbuch, A.
Postel-Vinay, S.
Goebeler, M. E.
Addeo, A.
Prenen, H.
Arkenau, T.
Sacher, A.
Liu, C.
Kormany, W.
Ahnert, J.
JOURNAL OF THORACIC ONCOLOGY, 2022, 17 (09) : S457 - S457

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