Phase I dose escalation and initial dose expansion results of AMG 193: A MTA-cooperative PRMT5 inhibitor, in patients (pts) with MTAP-deleted solid tumors

被引：0

作者：

Sacher, A. G. ^{[1
]}

Villalona-Calero, M. ^{[2
]}

O'Neil, B. H. ^{[3
]}

Rodon, J. ^{[4
]}

Doi, T. ^{[5
]}

Postel-Vinay, S. ^{[6
]}

Ghiringhelli, F. ^{[7
]}

Yamamoto, N. ^{[8
]}

Wahlroos, S. ^{[9
]}

Villaruz, L. ^{[10
]}

El-Helali, A. ^{[11
]}

Fujiwara, Y. ^{[12
]}

Addeo, A. ^{[13
]}

Lin, C-C. ^{[14
]}

Fontana, E. ^{[15
]}

Chuang, C-H. ^{[16
]}

Liu, C. ^{[16
]}

Eggert, T. ^{[17
]}

Penel, N. ^{[18
]}

Prenen, H. ^{[19
]}

机构：

[1] UHN Univ Hlth Network, Princess Margaret Canc Ctr, Med Oncol & Hematol Dept, Toronto, ON, Canada

[2] City Hope Natl Med Ctr, Med Oncol, Duarte, CA USA

[3] Community Hlth Network, Med Oncol, Indianapolis, IN USA

[4] MD Anderson Canc Ctr, Drug Dev Dept, Houston, TX USA

[5] Natl Canc Ctr Hosp East, Expt Therapeut Dept, Chiba, Japan

[6] Inst Gustave Roussy, Drug Dev Dept, Villejuif, France

[7] Univ Bourgogne Franche Comte, Med Oncol, Platform Transfer Canc Biol, Ctr Georges Francois Leclerc,INSERM,LNC,UMR1231, Dijon, France

[8] Natl Canc Ctr, Tsukiji Campus, Tokyo, Japan

[9] Chris OBrien Lifehouse, Med Oncol Dept, Camperdown, NSW, Australia

[10] UPMC Hillman Canc Ctr, Med Hem Onc Dept, Pittsburgh, PA USA

[11] HKU Univ Hong Kong, Dept Clin Oncol, Hong Kong, Peoples R China

[12] Aichi Canc Ctr Hosp, Thorac Oncol, Nagoya, Aichi, Japan

[13] HUG Hop Univ Geneve, Dept Oncol, Geneva, Switzerland

[14] Natl Taiwan Univ Hosp, Dept Oncol, Taipei, Taiwan

[15] Sarah Cannon Res Inst SCRI UK, Drug Dev, London, England

[16] Amgen Headquarters USA, Clin Biomarkers, Thousand Oaks, CA USA

[17] Amgen Headquarters USA, Transnat Med Dept, Thousand Oaks, CA USA

[18] Ctr Oscar Lambret, Med Oncol Dept, Lille, France

[19] UZA Univ Hosp Antwerp, Oncol Dept, Edegem, Belgium

来源：

ANNALS OF ONCOLOGY | 2024年 / 35卷

关键词：

D O I：

10.1016/j.annonc.2024.08.671

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

604O

引用

页码：S484 / S485

页数：2

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