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- [24] The Role of Vitamin D in Reproductive Health-A Trojan Horse or the Golden Fleece?NUTRIENTS, 2015, 7 (06): : 4139 - 4153Dabrowski, Filip A.Grzechocinska, BarbaraWielgos, Miroslaw
Extracellular vesicles in cancer: golden goose or Trojan horse
被引：0
|作者：
Han, Tao
[1
]
Hao, Qian
[2
,3
,4
]
Chao, Tengfei
[5
]
Sun, Qinggang
[1
,6
]
Chen, Yitian
[1
]
Gao, Bo
[7
]
Guan, Liping
Ren, Wenjie
[1
]
Zhou, Xiang
[2
,3
,4
,8
,9
]
机构：
[1] Xinxiang Med Univ, Inst Hlth Cent Plains, Xinxiang Key Lab Mol Oncol, Xinxiang 453003, Peoples R China
[2] Fudan Univ, Shanghai Canc Ctr, Shanghai 200032, Peoples R China
[3] Fudan Univ, Inst Biomed Sci, Shanghai 200032, Peoples R China
[4] Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai 200032, Peoples R China
[5] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Oncol, Wuhan 430030, Peoples R China
[6] Xinxiang Med Univ, Sch Basic Med Sci, Xinxiang 453003, Peoples R China
[7] Umibio Co Ltd, Shanghai 200030, Peoples R China
[8] Fudan Univ, Shanghai Canc Ctr, Key Lab Breast Canc Shanghai, Shanghai 200032, Peoples R China
[9] Fudan Univ, Inst Biomed Sci, Shanghai Key Lab Med Epigenet, Int Colab Med Epigenet & Metab,Minist Sci & Techno, Shanghai 200032, Peoples R China
基金：
中国国家自然科学基金;
关键词：
exosome;
tumor microenvironment;
immune response;
metastasis;
cancer therapy;
EXOSOME-MEDIATED DELIVERY;
IN-VITRO;
LYSOSOME BIOGENESIS;
THERAPY;
PROMOTE;
DISPLAY;
CHEMORESISTANCE;
MICROVESICLES;
SUPPRESSION;
INHIBITION;
D O I：
10.1093/jmcb/mjae025
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ;
090102 ;
摘要：
Intercellular communication can be mediated by direct cell-to-cell contact and indirect interactions through secretion of soluble chemokines, cytokines, and growth factors. Extracellular vesicles (EVs) have emerged as important mediators of cell-to-cell and cell to-environment communications. EVs from tumor cells, immune cells, and stromal cells can remodel the tumor microenvironment and promote cancer cell survival, proliferation, metastasis, immune evasion, and therapeutic resistance. Most importantly, EVs as natural nanoparticles can be manipulated to serve as a potent delivery system for targeted cancer therapy. EVs can be engineered or modified to improve their ability to target tumors and deliver therapeutic substances, such as chemotherapeutic drugs, nucleic acids, and proteins, for the treatment of cancer. This review provides an overview of the biogenesis and recycling of EVs, discusses their roles in cancer development, and highlights their potential as a delivery system for targeted cancer therapy.
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页数：10
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