Andrographolide and its Derivatives in Cardiovascular Disease: A Comprehensive Review

被引：0

作者：

Zhang, Shenjie ^{[1
]}

Xie, Xiaokai ^{[1
]}

Zhao, Juan ^{[2
]}

Jiang, Yilong ^{[1
]}

Huang, Chao ^{[3
]}

Li, Qi ^{[1
]}

Xia, Boyu ^{[1
]}

Yin, Le ^{[2
]}

Yuan, Xiaomei ^{[4
]}

You, Qingsheng ^{[1
]}

机构：

[1] Nantong Univ, Dept Cardiothorac Surg, Affiliated Hosp, Nantong, Peoples R China

[2] Tongzhou Peoples Hosp, Dept Cardiol, Nantong, Peoples R China

[3] Nantong Univ, Sch Pharm, Dept Pharmacol, Nantong, Peoples R China

[4] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Dept Cardiol, 32 Sect 2 West First Ring Rd, Chengdu 610072, Peoples R China

来源：

PLANTA MEDICA | 2025年

关键词：

andrographolide; cardiovascular disease; heart; CORONARY-HEART-DISEASE; NF-KAPPA-B; ATRIAL-FIBRILLATION; IN-VITRO; CARDIAC-HYPERTROPHY; OXIDATIVE STRESS; MYOCARDIAL-INFARCTION; SIGNALING PATHWAYS; PANICULATA EXTRACT; GENE-EXPRESSION;

D O I：

10.1055/a-2542-0756

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Cardiovascular disease is one of the main causes of mortality worldwide. Andrographolide represents an important category of natural phytochemicals that has significant therapeutic potential in various conditions such as acute lung injury, heart disease, and viral infections due to its anti-oxidative, anti-inflammatory, and anti-apoptotic properties. This compound plays a protective role in human pathophysiology. This review provides a comprehensive overview of the effects of andrographolide on cardiovascular disease and examines its essential roles and mechanisms in cardiovascular disease and other vascular dysfunctions. The data collected in this review serve as a comprehensive reference for the role of andrographolide in cardiovascular disease and provide valuable insights for further research and the development of andrographolide as a novel therapeutic approach for cardiovascular disease.

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页数：12

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