Sex-related differences in amyotrophic lateral sclerosis: A 2-[18F]FDG-PET study

被引：0

作者：

Canosa, Antonio ^{[1
,2
,3
]}

Martino, Alessio ^{[4
]}

Manera, Umberto ^{[1
,2
]}

Giuliani, Alessandro ^{[5
]}

Vasta, Rosario ^{[1
]}

Palumbo, Francesca ^{[1
]}

Grassano, Maurizio ^{[1
]}

Morbelli, Silvia Daniela ^{[6
,7
]}

Pardini, Matteo ^{[8
,9
]}

Chiaravalloti, Agostino ^{[10
,11
]}

Schillaci, Orazio ^{[10
]}

Leenders, Klaus Leonard ^{[12
,13
]}

Kogan, Rosalie Vered ^{[13
]}

Polverari, Giulia ^{[14
]}

Zocco, Grazia ^{[1
]}

Di Pede, Francesca ^{[1
]}

Mattei, Filippo De ^{[1
]}

Cabras, Sara ^{[1
,15
]}

Matteoni, Enrico ^{[1
]}

Moglia, Cristina ^{[1
,2
]}

Calvo, Andrea ^{[1
,2
,16
]}

Chio, Adriano ^{[1
,2
,3
,16
]}

Pagani, Marco ^{[3
,17
]}

机构：

[1] Univ Turin, Als Ctr, Rita Levi Montalcini Dept Neurosci, Via Cherasco 15, I-10126 Turin, Italy

[2] Azienda Osped Univ Citta Salute & Sci Torino, Neurol Unit 1U, Turin, Italy

[3] CNR, Inst Cognit Sci & Technol, Rome, Italy

[4] Luiss Univ, Dept Business & Management, Rome, Italy

[5] Ist Super Sanita, Environm & Hlth Dept, I-00161 Rome, Italy

[6] Univ Turin, Dept Med Sci, Turin, Italy

[7] Azienda Osped Univ Citta Salute & Sci Torino, Nucl Med Unit, Turin, Italy

[8] Univ Genoa, Dept Neurosci Rehabil Ophthalmol Genet Maternal &, Genoa, Italy

[9] IRCCS Osped Policlin San Martino, Genoa, Italy

[10] Univ Roma Tor Vergata, Dept Biomed & Prevent, Rome, Italy

[11] IRCCS Neuromed, Pozzilli, Italy

[12] Univ Groningen, Univ Med Ctr Groningen, Dept Neurol, Groningen, Netherlands

[13] Univ Groningen, Univ Med Ctr Groningen, Dept Nucl Med & Mol Imaging, Groningen, Netherlands

[14] Positron Emiss Tomog Ctr AFFIDEA IRMET SpA, Turin, Italy

[15] Univ Camerino, Ctr Neurosci, Camerino, Italy

[16] Neurosci Inst Turin, Turin, Italy

[17] Karolinska Univ Hosp, Dept Med Radiat Phys & Nucl Med, Stockholm, Sweden

来源：

EUROPEAN JOURNAL OF NEUROLOGY | 2025年 / 32卷 / 01期

关键词：

2-[F-18]FDG-PET; amyotrophic lateral sclerosis; brain connectivity; brain metabolism; sex differences; MODULATE DISEASE PROGRESSION; RAT MODEL; FDG-PET; BRAIN; ALS; RISK; TOMOGRAPHY; DIMORPHISM; TRENDS;

D O I：

10.1111/ene.16588

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Purpose: We investigated sex-related brain metabolic differences in Amyotrophic Lateral Sclerosis (ALS) and healthy controls (HC). Methods: We collected two equal-sized groups of male (m-ALS) and female ALS (f-ALS) patients (n = 130 each), who underwent 2-[F-18]FDG-PET at diagnosis, matched for site of onset, cognitive status and King's stage. We included 168 age-matched healthy controls, half female (f-HC) and half male (m-HC). We compared brain metabolism of males and females separately for ALS and HC, including age as covariate. A differential network analysis was performed to evaluate brain connectivity. Results: M-ALS showed relative hypometabolism of bilateral medial frontal, parietal and occipital cortices, and left temporal cortex, compared to f-ALS. In node-wise comparison, f-ALS showed significantly higher connectivity in right middle cingulate cortex and left superior and medial frontal gyrus. In HC we did not find any sex-related differences. Conclusion: Sex resulted a major determinant of brain metabolism and connectivity in ALS patients.

引用

页数：11

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