Analysis of Repeat Step-up Dosing and Cytokine Release Syndrome Events Following Prolonged Dosing Intervals of Teclistamab in the Phase 1/2 Majestec-1 Study

被引：0

作者：

van de Donk, Niels W. C. J. ^{[1
]}

Chari, Ajai ^{[2
]}

Karlin, Lionel ^{[3
]}

Krishnan, Amrita Y. ^{[4
]}

Uttervall, Katarina ^{[5
]}

Chalopin, Thomas ^{[6
]}

Dachs, Laura Rosinol ^{[7
]}

Oriol, Albert ^{[8
,9
]}

Matous, Jeffrey, V ^{[10
]}

Bhutani, Manisha ^{[11
]}

Rodriguez, Cesar ^{[12
]}

Carde, Natalia Quijano ^{[13
]}

Guo, Yue ^{[13
]}

Hodin, Caroline ^{[14
]}

Uhlar, Clarissa ^{[13
]}

Stephenson, Tara ^{[13
]}

Zuppa, Athena ^{[15
]}

Doyle, Margaret ^{[16
]}

Chastain, Katherine ^{[15
]}

Garfall, Alfred ^{[17
]}

机构：

[1] Vrije Univ Amsterdam, Amsterdam Univ, Med Ctr, Amsterdam, Netherlands

[2] Univ Calif San Francisco, San Francisco, CA USA

[3] Ctr Hosp Lyon Sud, Pierre Benite, France

[4] City Hope Comprehens Canc Ctr, Duarte, CA USA

[5] Karolinska Univ Hosp, Stockholm, Sweden

[6] Ctr Hosp Univ Tours, Tours, France

[7] Hosp Clin Barcelona, IDIBAPS, Barcelona, Spain

[8] Hosp Germans Trias i Pujol, Inst Catala Oncol, Barcelona, Spain

[9] Hosp Germans Trias i Pujol, Inst Josep Carreras, Barcelona, Spain

[10] Sarah Cannon Res Inst, Colorado Blood Canc Inst, Denver, CO USA

[11] Atrium Hlth, Levine Canc Inst, Wake Forest Sch Med, Charlotte, NC USA

[12] Icahn Sch Med Mt Sinai, Tisch Canc Inst, Dept Med Hematol & Med Oncol, New York, NY USA

[13] Janssen Res & Dev, Spring House, PA USA

[14] Janssen Res & Dev, Beerse, Belgium

[15] Janssen Res & Dev, Raritan, NJ USA

[16] Janssen Global Serv, Dublin, Ireland

[17] Univ Penn, Perelman Sch Med, Abramson Canc Ctr, Philadelphia, PA USA

来源：

BLOOD | 2024年 / 144卷

关键词：

D O I：

10.1182/blood-2024-200344

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：4735 / 4735

页数：1

共 34 条

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[22] Updated Results from MajesTEC-1: Phase 1/2 Study of Teclistamab, a B-Cell Maturation Antigen x CD3 Bispecific Antibody, in Relapsed/Refractory Multiple Myeloma
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Garfall, Alfred L.
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BLOOD, 2021, 138
[23] Subgroup Analysis of Adverse Events Following Rusfertide Dosing in Revive: A Phase 2 Study of Patients with Polycythemia Vera
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[24] Updated Results From the Phase 1/2 MajesTEC-1 Study of Teclistamab, a B-Cell Maturation Antigen x CD3 Bispecific Antibody, in Patients with Relapsed/Refractory Multiple Myeloma
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[25] ABBV-383, a BCMA-CD3 bispecific antibody, in relapsed/refractory multiple myeloma: a multicenter, phase 1b dose optimization study with step-up dosing
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[26] A phase 2 randomized multicenter study of 2 extended dosing schedules of oral ezatiostat in low to intermediate-1 risk myelodysplastic syndrome
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[27] Cytokine Release Syndrome in Patients with Relapsed/Refractory Multiple Myeloma Treated with Ciltacabtagene Autoleucel in the Phase 1b/2 CARTITUDE-1 Study
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[28] Prophylactic Tocilizumab to Mitigate Cytokine Release Syndrome in Patients Receiving Talquetamab for Relapsed/Refractory Multiple Myeloma: Results From the Phase 1/2 MonumenTAL-1 Study
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[29] Phase 2 Randomized Multicenter Study of Extended Dosing Schedules of Oral Ezatiostat HCl (Telintra), a Glutathione Analog Prodrug GSTP1-1 Inhibitor, In Low to Intermediate-1 Risk Myelodysplastic Syndrome (MDS)
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[30] Subcutaneous (SC) Administration of Mosunetuzumab with Cycle 1 Step- up Dosing Is Tolerable and Active in Patients with Relapsed/Refractory B-Cell NonHodgkin Lymphomas (R/R B-NHL): Initial Results from a Phase I/II Study
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