Associations between genetic variations in oxytocin pathway genes and hippocampal volume: Insights from the UK Biobank

被引：0
|
作者：
Xiao, Shanshan [1 ,2 ]
Ebner, Natalie C. [3 ,4 ,5 ]
Dang, Junhua [6 ]
Rukh, Gull [2 ]
Westberg, Lars [7 ]
Schioth, Helgi B. [2 ]
Fischer, Hakan [1 ,8 ,9 ,10 ]
机构：
[1] Stockholm Univ, Dept Psychol, Albanovagen 12, SE-11419 Stockholm, Sweden
[2] Uppsala Univ, Dept Surg Sci Funct Pharmacol & Neurosci, Uppsala, Sweden
[3] Univ Florida, Dept Psychol, Gainesville, FL USA
[4] Univ Florida, Cognit Aging & Memory Program, Clin Translat Res Program CAM CTRP, Gainesville, FL USA
[5] Univ Florida, McKnight Brain Inst, Gainesville, FL USA
[6] Xi An Jiao Tong Univ, Sch Humanities & Social Sci, Inst Social Psychol, Xian, Shaanxi, Peoples R China
[7] Univ Gothenburg, Inst Neurosci & Physiol, Sahlgrenska Acad, Dept Pharmacol, Gothenburg, Sweden
[8] Stockholm Univ, Brain Imaging Ctr SUBIC, Stockholm, Sweden
[9] Karolinska Inst, Aging Res Ctr, Stockholm, Sweden
[10] Stockholm Univ, Stockholm, Sweden
来源：
CORTEX | 2025年 / 183卷
基金：
瑞典研究理事会;
关键词：
Oxytocin pathway gene; Oxytocin receptor; Hippocampus; Social recognition memory; UK Biobank; INTRANASAL OXYTOCIN; BRAIN STRUCTURE; RECEPTOR GENE; I OXT; EXPRESSION; DEFICITS; HUMANS; SYSTEM;
D O I：
10.1016/j.cortex.2024.11.017
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
The role of oxytocin-related genes in social-cognitive function has been previously established, but structural brain mechanisms underlying this link remain poorly understood. Utilizing a substantial dataset from the UK Biobank (N z 30,000), this research determined associations between variations in ten single nucleotide polymorphisms (SNPs) within three oxytocin pathway genes (i.e., the oxytocin/neurophysin I prepropetide gene, the cluster of differentiation 38 glycoprotein gene, the oxytocin receptor gene) and whole-brain gray matter volume. Carriers of the AA or AG genotypes of the oxytocin receptor gene rs237851 SNP exhibited significantly larger hippocampal volume than carriers of the GG genotype. These results support the link between variations in the oxytocin receptor gene and hippocampal structure, with possible impact on social-cognitive function such as social recognition memory. (c) 2024 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
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收藏
页码：211 / 219
页数：9
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