case report;
neurofibromatosis type 1;
gastrointestinal stromal tumors;
neuroendocrine tumors;
surufatinib;
D O I:
10.3389/fonc.2024.1336539
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
Neurofibromatosis type 1 (NF-1) is commonly associated with a variety of rare tumors. However, no case of multiple gastric gastrointestinal stromal tumors (GISTs) or duodenal ampulla neuroendocrine tumors (NETs) with multiple liver metastases in a patient with NF-1 has yet been reported. Here, we describe a case of a 55-year-old female patient with NF-1 whose serum Pro-Gastrin-Releasing Peptide (pro-GRP) levels were elevated. Gastrointestinal endoscopy and biopsy showed duodenal papilla space-occupying mass, and the pathological diagnosis turned out to be neuroendocrine tumors (NETs). During surgical exploration, multiple tumors were found on the serosal surface of the stomach and numerous miliary metastases in the liver. Following histopathological examination, it was determined that the liver metastases were NF-1 and the tumors in the gastric wall were GISTs. The patient benefited from targeted therapy and had an uneventful hospital stay. In this case, we emphasize treating patients with neurofibromatosis type 1 who exhibit abdominal symptoms with a high degree of clinical suspicion and performing thorough evaluations to rule out multiple tumors.
机构:
Department of Medical Oncology, Gaziantep University, School of Medicine, Gaziantep Oncology Hospital, Gaziantep TR-27310, TurkeyDepartment of Medical Oncology, Gaziantep University, School of Medicine, Gaziantep Oncology Hospital, Gaziantep TR-27310, Turkey
机构:
Ankara Ataturk Egtim & Arastirma Hastanesi, Genel Cerrahi Klin, Ankara, TurkeyAnkara Ataturk Egtim & Arastirma Hastanesi, Genel Cerrahi Klin, Ankara, Turkey
Dumlu, Ersin Gurkan
Ozdedeoglu, Mesut
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Ankara Ataturk Egtim & Arastirma Hastanesi, Genel Cerrahi Klin, Ankara, TurkeyAnkara Ataturk Egtim & Arastirma Hastanesi, Genel Cerrahi Klin, Ankara, Turkey
Ozdedeoglu, Mesut
Gurer, Ahmet
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Ankara Ataturk Egtim & Arastirma Hastanesi, Genel Cerrahi Klin, Ankara, TurkeyAnkara Ataturk Egtim & Arastirma Hastanesi, Genel Cerrahi Klin, Ankara, Turkey
Gurer, Ahmet
Kilic, Ibrahim
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Ankara Ataturk Egtim & Arastirma Hastanesi, Genel Cerrahi Klin, Ankara, TurkeyAnkara Ataturk Egtim & Arastirma Hastanesi, Genel Cerrahi Klin, Ankara, Turkey
Kilic, Ibrahim
Kiyak, Gulten
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Ankara Ataturk Egtim & Arastirma Hastanesi, Genel Cerrahi Klin, Ankara, TurkeyAnkara Ataturk Egtim & Arastirma Hastanesi, Genel Cerrahi Klin, Ankara, Turkey