Epigenetic and epitranscriptomic role of lncRNA in carcinogenesis (Review)

被引：0

作者：

Dai, Chunfei ^{[1
,2
]}

Qianjiang, Haoyue ^{[1
,2
]}

Fu, Ruishuang ^{[1
]}

Yang, Huimin ^{[1
]}

Shi, Aiqin ^{[3
]}

Luo, Huacheng ^{[1
]}

机构：

[1] Chinese Acad Sci, Zhejiang Canc Hosp, Hangzhou Inst Med, Key Lab Zhejiang Prov Aptamers & Theranost, 150 Fucheng Rd, Hangzhou 310022, Zhejiang, Peoples R China

[2] Zhejiang Univ Technol, Coll Pharm, Hangzhou 310014, Zhejiang, Peoples R China

[3] Xianghu Lab, Hangzhou 311231, Zhejiang, Peoples R China

来源：

INTERNATIONAL JOURNAL OF ONCOLOGY | 2025年 / 66卷 / 04期

基金：

中国国家自然科学基金;

关键词：

long non-coding RNA; chromatin modification; epigenetic regulation; epitranscriptomic regulation; carcinogenesis; LONG NONCODING RNA; BREAST-CANCER CELLS; DNA METHYLATION; PROSTATE-CANCER; UNIQUE FEATURES; GENE-REGULATION; CHROMATIN; EXPRESSION; PROLIFERATION; METASTASIS;

D O I：

10.3892/ijo.2025.5735

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Long non-coding RNAs (lncRNAs) are key players in the regulation of gene expression by mediating epigenetic and epitranscriptomic modification. Dysregulation of lncRNAs is implicated in tumor initiation, progression and metastasis. lncRNAs modulate chromatin structure and gene transcription by recruiting epigenetic regulators, including DNA- or histone-modifying enzymes. Additionally, lncRNAs mediate chromatin remodeling and enhancer-promoter long-range chromatin interactions to control oncogene expression by recruiting chromatin organization-associated proteins, thereby promoting carcinogenesis. Furthermore, lncRNAs aberrantly induce oncogene expression by mediating epitranscriptomic modifications, including RNA methylation and RNA editing. The present study aimed to summarize the regulatory mechanisms of lncRNAs in cancer to unravel the complex interplay between lncRNAs and epigenetic/epitranscriptomic regulators in carcinogenesis. The present review aimed to provide a novel perspective on the epigenetic and epitranscriptomic roles of lncRNAs in carcinogenesis to facilitate identification of potential biomarkers and therapeutic targets for cancer diagnosis and treatment.

引用

页数：15

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