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Unlocking Potential: A Comprehensive Overview of Cell Culture Banks and Their Impact on Biomedical Research
被引:1
|作者:
Weiskirchen, Sabine
[1
]
Monteiro, Antonio M.
[2
]
Borojevic, Radovan
[2
]
Weiskirchen, Ralf
[1
]
机构:
[1] Univ Hosp Aachen, Inst Mol Pathobiochem Expt Gene Therapy & Clin Che, D-52074 Aachen, Germany
[2] Banco Celulas Rio De Janeiro, BR-25250020 Rio De Janeiro, Brazil
来源:
关键词:
cell culture banks;
quality control;
biomedical research;
biobanking technology;
ICLAC;
cell authentication;
contamination;
immortalized cell lines;
drug development;
3R principle;
PCR;
IDENTIFICATION;
LINES;
D O I:
10.3390/cells13221861
中图分类号:
Q2 [细胞生物学];
学科分类号:
071009 ;
090102 ;
摘要:
Cell culture banks play a crucial role in advancing biomedical research by providing standardized, reproducible biological materials essential for various applications, from drug development to regenerative medicine. This opinion article presents a comprehensive overview of cell culture banks, exploring their establishment, maintenance, and characterization processes. The significance of ethical considerations and regulatory frameworks governing the use of cell lines is discussed, emphasizing the importance of quality control and validation in ensuring the integrity of research outcomes. Additionally, the diverse types of cell culture banks-primary cells, immortalized cell lines, and stem cells-and their specific contributions to different fields such as cancer research, virology, and tissue engineering are examined. The impact of technological advancements on cell banking practices is also highlighted, including automation and biobanking software that enhance efficiency and data management. Furthermore, challenges faced by researchers in accessing high-quality cell lines are addressed, along with proposed strategies for improving collaboration between academic institutions and commercial entities. By unlocking the potential of cell culture banks through these discussions, this article aims to underline their indispensable role in driving innovation within biomedical research and fostering future discoveries that could lead to significant therapeutic breakthroughs.
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页数:21
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