Innovative salicylic acid microsponges for sustained drug release

被引：0
|
作者：
Zheng, Juanping [1 ]
Su, Junzhao [1 ]
Luo, Hongsheng [1 ]
Yang, Wenhui [1 ]
Yu, Tianhao [2 ]
机构：
[1] Guangdong Univ Technol, Sch Chem Engn & Light Ind, Guangzhou 510006, Peoples R China
[2] Jinan Univ, Affiliated Guangdong Prov Gen Hosp 2, Dept Cardiol, Guangzhou 510314, Guangdong, Peoples R China
来源：
MATERIALS LETTERS | 2025年 / 382卷
关键词：
Salicylic acid; Microsponges; Optimization; Sustained release; Hydrogel;
D O I：
10.1016/j.matlet.2024.137875
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
A novel salicylic acid microsponge was prepared using the quasi-emulsion solvent diffusion method. The yield, encapsulation efficiency, morphology, thermal properties, drug state, in vitro release, and application potential were systematically evaluated. The optimized microsponges demonstrated a yield of 84.92 % and an encapsulation efficiency of 68.69 %. The morphology of the microsponges exhibited a porous spherical structure. Additionally, the interaction between salicylic acid (SA) and ethyl cellulose (EC) enhanced the thermal stability of the microsponges and significantly reduced the crystallinity of SA. These microsponges exhibited excellent sustained release characteristics, enabling drug release for up to 78 h. Finally, combining the SA microsponges with the Carbopol 934 hydrogel system demonstrated favorable viscoelasticity, creep recovery, and stability, providing new insights for its application in dermatological treatments.
引用
收藏
页数：4
相关论文
共 50 条
  • [31] Prepare and release of the chitosan sustained-release drug microspheres
    School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China
    Gongneng Cailiao, 2009, 6 (959-961+965):
  • [32] Substituted amylose as a matrix for sustained drug release
    Chebli, C
    Moussa, I
    Buczkowski, S
    Cartilier, L
    PHARMACEUTICAL RESEARCH, 1999, 16 (09) : 1436 - 1440
  • [33] Sustained release formulations for spinal drug delivery
    Lagarce, F
    Benoit, JP
    JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2004, 14 (05) : 331 - 343
  • [34] Substituted Amylose as a Matrix for Sustained Drug Release
    Chafic Chebli
    Iskandar Moussa
    Stéphane Buczkowski
    Louis Cartilier
    Pharmaceutical Research, 1999, 16 : 1436 - 1440
  • [35] HYDROGEL CAPSULES FOR SUSTAINED DRUG-RELEASE
    RAMARAJ, B
    RADHAKRISHNAN, G
    JOURNAL OF APPLIED POLYMER SCIENCE, 1994, 51 (06) : 979 - 988
  • [36] Delivery strategies for sustained drug release in the lungs
    Loira-Pastoriza, Cristina
    Todoroff, Julie
    Vanbever, Rita
    ADVANCED DRUG DELIVERY REVIEWS, 2014, 75 : 81 - 91
  • [37] Biodegradable Implants for Sustained Drug Release in the Eye
    Susan S. Lee
    Patrick Hughes
    Aron D. Ross
    Michael R. Robinson
    Pharmaceutical Research, 2010, 27 : 2043 - 2053
  • [38] Sustained Release Drug Delivery Applications of Polyurethanes
    Lowinger, Michael B.
    Barrett, Stephanie E.
    Zhang, Feng
    Williams, Robert O., III
    PHARMACEUTICS, 2018, 10 (02):
  • [39] Sustained Drug Release from Contact Lenses
    Ferreira, J. A.
    Oliveira, P.
    Silva, P. M.
    Carreira, A.
    Gil, H.
    Murta, J. N.
    CMES-COMPUTER MODELING IN ENGINEERING & SCIENCES, 2010, 60 (02): : 151 - 179
  • [40] Sustained drug release from contact lenses
    Ferreira, J.A.
    Oliveira, P.
    Silva, P.M.
    Carreira, A.
    Gil, H.
    Murta, J.N.
    CMES - Computer Modeling in Engineering and Sciences, 2010, 60 (02): : 151 - 179
12345