Metal-Free Multicatalytic Decarbonylation of Aldehydes Driven by Light

被引：0

作者：

Nouaille, Augustin ^{[1
]}

Terzani, Francesco ^{[1
]}

Fakih, Yara ^{[1
]}

Hannedouche, Jerome ^{[2
]}

Magnier, Emmanuel ^{[1
]}

Gosmini, Corinne ^{[2
,3
]}

Dagousset, Guillaume ^{[1
,4
]}

机构：

[1] Univ Paris Saclay, Inst Lavoisier Versailles, UVSQ, CNRS UMR 8180, 45 ave Etats Unis, F-78035 Versailles, France

[2] Univ Paris Saclay, Inst Chim Mol & Materiaux Orsay ICMMO, CNRS UMR 8182, Batiment Henri Moissan, 17 avenue Sci, F-91400 Orsay, France

[3] Ecole Polytech, Inst Polytech Paris, Lab Chim Mol, CNRS Route Saclay, F-91128 Palaiseau, France

[4] Univ Paris Saclay, BioCIS, UMR 8076, 17 ave Sci, F-91400 Orsay, France

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2025年

关键词：

decarbonylation; metal-free; photocatalysis; organocatalysis; aldehydes; CATALYTIC DECARBONYLATION; RADICAL CHEMISTRY; HYDROFUNCTIONALIZATION;

D O I：

10.1002/anie.202424459

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A metal-free dual photo- and organocatalytic decarbonylation of aliphatic aldehydes is described for the first time. On the one hand, a wide range of tertiary aldehydes are smoothly decarbonylated thanks to the combination of thioxanthone as photocatalyst and diphenyl disulfide as organocatalyst. On the other hand, by simply using 4-CzIPN as photocatalyst instead of thioxanthone, various secondary aldehydes readily undergo decarbonylation in an orthogonal manner, via the in situ formation of 1,4-dihydropyridines. Both methodologies are compatible with various functional groups and are readily applied to the decarbonylation of complex molecules.

引用

页数：7

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