Joint contribution of polygenic scores for depression and attention-deficit/hyperactivity disorder to youth suicidal ideation and attempt

被引：0

作者：

Orri, Massimiliano ^{[1
,2
,3
]}

Morneau-Vaillancourt, Genevieve ^{[4
,5
]}

Ouellet-Morin, Isabelle ^{[5
,6
]}

Cortese, Samuele ^{[7
,8
,9
,10
,11
]}

Galera, Cedric ^{[12
,13
,14
]}

Voronin, Ivan ^{[15
]}

Vitaro, Frank ^{[16
]}

Brendgen, Mara R. ^{[17
]}

Dionne, Ginette ^{[15
]}

Paquin, Stephane ^{[18
]}

Forte, Alberto ^{[19
]}

Turecki, Gustavo ^{[1
]}

Tremblay, Richard E. ^{[20
]}

Cote, Sylvana M. ^{[21
]}

Geoffroy, Marie-Claude ^{[1
,2
]}

Boivin, Michel ^{[14
]}

机构：

[1] McGill Univ, Dept Psychiat, Douglas Mental Hlth Univ Inst, McGill Grp Suicide Studies, Montreal, PQ, Canada

[2] McGill Univ, Sch Populat & Global Hlth, Dept Epidemiol Biostat & Occupat Hlth, Montreal, PQ, Canada

[3] Danish Res Inst Suicide Prevent, Mental Hlth Ctr Copenhagen, Copenhagen, Denmark

[4] Kings Coll London, Inst Psychiat Psychol & Neurosci IoPPN, Social Genet & Dev Psychiat Ctr SGDP, London, England

[5] Univ Montreal, Ecole Criminol, Montreal, PQ, Canada

[6] Univ Montreal, Res Ctr Montreal Mental Hlth Univ Inst, Montreal, PQ, Canada

[7] Univ Southampton, Fac Environm & Life Sci, Ctr Innovat Mental Hlth, Sch Psychol, Southampton, England

[8] Univ Southampton, Fac Med, Clin & Expt Sci CNS & Psychiat, Southampton, England

[9] Solent NHS Trust, Southampton, England

[10] NYU, NYU Langone, Child Study Ctr, Hassenfeld Childrens Hosp, New York, NY USA

[11] Univ Bari Aldo Moro, DiMePRe J Dept Precis & Rigenerat Med Jon Area, Bari, Italy

[12] Univ Bordeaux, Dept Child & Adolescent Psychiat, Bordeaux, France

[13] Ctr Hosp Perrens, Bordeaux, France

[14] Bordeaux Populat Hlth, INSERM U1219, Bordeaux, France

[15] Univ Laval, Ecole Psychol, Quebec City, PQ, Canada

[16] Univ Montreal, Ecole Psychoeduc, Montreal, PQ, Canada

[17] Univ Quebec Montreal, Dept Psychol, Montreal, PQ, Canada

[18] Penn State Univ, Dept Psychol, State Coll, PA USA

[19] Univ Hosp Lausanne CHUV, Dept Psychiat, Div Child & Adolescent Psychiat, Lausanne, Switzerland

[20] Univ Montreal, Dept Pediat & Psychol, Montreal, PQ, Canada

[21] Univ Montreal, Dept Med Sociale & Prevent, Montreal, PQ, Canada

来源：

MOLECULAR PSYCHIATRY | 2025年

基金：

加拿大健康研究院; 加拿大魁北克医学研究基金会;

关键词：

DEFICIT HYPERACTIVITY DISORDER; DECISION-MAKING; COMORBIDITY; ADOLESCENTS; RISK; ASSOCIATIONS; TRAJECTORIES; IMPULSIVITY; PREDICTORS; BEHAVIORS;

D O I：

10.1038/s41380-025-02989-z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Children presenting comorbid attention-deficit/hyperactivity disorder (ADHD) and depression symptoms have higher risks of later suicidal ideation and attempt. However, it is unclear to what extent this risk stems from individual differences in the genetic predisposition for ADHD and/or depression. We investigated the unique and combined contribution of genetic predisposition to ADHD and depression to suicidal ideation and attempt by early adulthood. Data were from two longitudinal population-based birth cohorts, the Quebec Longitudinal Study of Child Development and the Quebec Newborn Twin Study (total N = 1207). Genetic predisposition for ADHD and depression were measured using polygenic scores. Suicidal ideation and attempt by age 20 years were self-reported via questionnaires. Across the two cohorts, suicidal ideation and attempt were reported by 99 (8.2%) and 75 (6.1%) individuals, respectively. A higher polygenic score for depression was associated with significantly higher risk of suicidal ideation and attempt, while no significant associations were found for ADHD polygenic score. However, we found an interaction between polygenic scores for depression and ADHD in the association with suicide attempt (P = 0.012), but not suicidal ideation (P = 0.897). The association between polygenic score for depression and suicide attempt was significantly stronger for individuals with a higher polygenic score for ADHD. Individuals scoring >= 1-SD above the mean for both polygenic scores were at increased risk for suicide attempt compared to individuals with lower scores (OR 4.03, CI 1.64-9.90), as well as compared to individuals scoring >= 1-SD above the mean in only depression (OR 2.92, CI 1.01-8.50) or only ADHD (OR 4.88, CI 1.56-15.26) polygenic scores. Our findings suggest that genetic predisposition for ADHD and depression contributes to increase the risk of suicide attempt in a multiplicative, rather that additive, way. Our results contribute to our understanding of the etiology of suicide risk and may inform screening and risk stratification.

引用

页数：9

共 50 条

[31] Attention-deficit hyperactivity disorder
不详
POSTGRADUATE MEDICINE, 1996, 100 (03) : 338 - 338
[32] Attention-deficit hyperactivity disorder
Hirsch, GS
Koplewicz, HS
EPILEPSY AND DEVELOPMENTAL DISABILITIES, 2002, : 187 - 204
[33] Attention-deficit/hyperactivity disorder
Stephen V. Faraone
Philip Asherson
Tobias Banaschewski
Joseph Biederman
Jan K. Buitelaar
Josep Antoni Ramos-Quiroga
Luis Augusto Rohde
Edmund J. S. Sonuga-Barke
Rosemary Tannock
Barbara Franke
Nature Reviews Disease Primers, 1
[34] Attention-deficit/hyperactivity disorder
Nature Reviews Disease Primers, 10
[35] ATTENTION-DEFICIT HYPERACTIVITY DISORDER
WEISS, G
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE, 1993, 38 (06): : 443 - 443
[36] ATTENTION-DEFICIT HYPERACTIVITY DISORDER
STEIN, MA
LEVENTHAL, BL
NEW ENGLAND JOURNAL OF MEDICINE, 1993, 329 (13): : 966 - 966
[37] Attention-Deficit/Hyperactivity Disorder
Rajaprakash, Meghna
Leppert, Mary L.
PEDIATRICS IN REVIEW, 2022, 43 (03) : 135 - 147
[38] Attention-deficit/hyperactivity disorder
Petermann, Franz
Hampel, Petra
KINDHEIT UND ENTWICKLUNG, 2009, 18 (03): : 135 - 136
[39] Attention-Deficit Hyperactivity Disorder
Bahn, Geon-Ho
JOURNAL OF THE KOREAN MEDICAL ASSOCIATION, 2005, 48 (11): : 1110 - 1118
[40] Attention-deficit/hyperactivity disorder
Schweitzer, JB
Cummins, TK
Kant, CA
MEDICAL CLINICS OF NORTH AMERICA, 2001, 85 (03) : 757 - +

← 1 2 3 4 5 →