Interactions between tumor-associated macrophages and regulated cell death: therapeutic implications in immuno-oncology

被引:0
|
作者
Ge, Yifei [1 ]
Jiang, Lixue [2 ]
Yang, Chengru [1 ]
Dong, Qingfu [1 ]
Tang, Chengwu [3 ]
Xu, Yi [1 ,3 ,4 ,5 ,6 ,7 ,8 ]
Zhong, Xiangyu [1 ]
机构
[1] Harbin Med Univ, Affiliated Hosp 2, Dept Hepatopancreatobiliary Surg, Harbin, Heilongjiang, Peoples R China
[2] Harbin Med Univ, Affiliated Hosp 2, Dept Breast Surg, Harbin, Heilongjiang, Peoples R China
[3] Huzhou Univ, Affiliated Hosp 1, Dept Hepatopancreatobiliary Surg, Huzhou Key Lab Translat Med, Huzhou, Zhejiang, Peoples R China
[4] Wenzhou Med Univ, Affiliated Hosp 1, Key Lab Clin Lab Diag & Translat Res Zhejiang Prov, Wenzhou, Zhejiang, Peoples R China
[5] Guangxi Med Univ, Natl Ctr Int Res Biotargeting Theranost, Collaborat Innovat Ctr Targeting Tumor Diag & Ther, State Key Lab Targeting Oncol,Guangxi Key Lab Biot, Nanning, Peoples R China
[6] Fujian Prov Key Lab Tumor Biotherapy, Fuzhou, Fujian, Peoples R China
[7] Fujian Prov Key Lab Translat Canc Med, Fuzhou, Fujian, Peoples R China
[8] Univ Hong Kong, Li Ka Shing Fac Med, Dept Pathol, Hong Kong, Peoples R China
来源
FRONTIERS IN ONCOLOGY | 2024年 / 14卷
基金
中国国家自然科学基金;
关键词
tumor-associated macrophages; regulated cell death; tumor microenvironment; ferroptosis; pyroptosis; necroptosis; apoptosis; cancer therapy; MIXED LINEAGE KINASE; DOMAIN-LIKE PROTEIN; BREAST-CANCER; FERROPTOSIS; PYROPTOSIS; INDUCE; METASTASIS; METABOLISM; EXPRESSION; APOPTOSIS;
D O I
10.3389/fonc.2024.1449696
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Tumor-associated macrophages (TAMs) play a pivotal role in sculpting the tumor microenvironment and influencing cancer progression, particularly through their interactions with various forms of regulated cell death (RCD), including apoptosis, pyroptosis, ferroptosis, and necroptosis. This review examines the interplay between TAMs and these RCD pathways, exploring the mechanisms through which they interact to promote tumor growth and advancement. We examine the underlying mechanisms of these intricate interactions, emphasizing their importance in cancer progression and treatment. Moreover, we present potential therapeutic strategies for targeting TAMs and manipulating RCD to enhance anti-tumor responses. These strategies encompass reprogramming TAMs, inhibiting their recruitment, and selectively eliminating them to enhance anti-tumor functions, alongside modulating RCD pathways to amplify immune responses. These insights offer a novel perspective on tumor biology and provide a foundation for the development of more efficacious cancer therapies.
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页数:17
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