Interactions between tumor-associated macrophages and regulated cell death: therapeutic implications in immuno-oncology

被引:0
|
作者
Ge, Yifei [1 ]
Jiang, Lixue [2 ]
Yang, Chengru [1 ]
Dong, Qingfu [1 ]
Tang, Chengwu [3 ]
Xu, Yi [1 ,3 ,4 ,5 ,6 ,7 ,8 ]
Zhong, Xiangyu [1 ]
机构
[1] Harbin Med Univ, Affiliated Hosp 2, Dept Hepatopancreatobiliary Surg, Harbin, Heilongjiang, Peoples R China
[2] Harbin Med Univ, Affiliated Hosp 2, Dept Breast Surg, Harbin, Heilongjiang, Peoples R China
[3] Huzhou Univ, Affiliated Hosp 1, Dept Hepatopancreatobiliary Surg, Huzhou Key Lab Translat Med, Huzhou, Zhejiang, Peoples R China
[4] Wenzhou Med Univ, Affiliated Hosp 1, Key Lab Clin Lab Diag & Translat Res Zhejiang Prov, Wenzhou, Zhejiang, Peoples R China
[5] Guangxi Med Univ, Natl Ctr Int Res Biotargeting Theranost, Collaborat Innovat Ctr Targeting Tumor Diag & Ther, State Key Lab Targeting Oncol,Guangxi Key Lab Biot, Nanning, Peoples R China
[6] Fujian Prov Key Lab Tumor Biotherapy, Fuzhou, Fujian, Peoples R China
[7] Fujian Prov Key Lab Translat Canc Med, Fuzhou, Fujian, Peoples R China
[8] Univ Hong Kong, Li Ka Shing Fac Med, Dept Pathol, Hong Kong, Peoples R China
来源
FRONTIERS IN ONCOLOGY | 2024年 / 14卷
基金
中国国家自然科学基金;
关键词
tumor-associated macrophages; regulated cell death; tumor microenvironment; ferroptosis; pyroptosis; necroptosis; apoptosis; cancer therapy; MIXED LINEAGE KINASE; DOMAIN-LIKE PROTEIN; BREAST-CANCER; FERROPTOSIS; PYROPTOSIS; INDUCE; METASTASIS; METABOLISM; EXPRESSION; APOPTOSIS;
D O I
10.3389/fonc.2024.1449696
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Tumor-associated macrophages (TAMs) play a pivotal role in sculpting the tumor microenvironment and influencing cancer progression, particularly through their interactions with various forms of regulated cell death (RCD), including apoptosis, pyroptosis, ferroptosis, and necroptosis. This review examines the interplay between TAMs and these RCD pathways, exploring the mechanisms through which they interact to promote tumor growth and advancement. We examine the underlying mechanisms of these intricate interactions, emphasizing their importance in cancer progression and treatment. Moreover, we present potential therapeutic strategies for targeting TAMs and manipulating RCD to enhance anti-tumor responses. These strategies encompass reprogramming TAMs, inhibiting their recruitment, and selectively eliminating them to enhance anti-tumor functions, alongside modulating RCD pathways to amplify immune responses. These insights offer a novel perspective on tumor biology and provide a foundation for the development of more efficacious cancer therapies.
引用
收藏
页数:17
相关论文
共 50 条
  • [1] Tumor-Associated Macrophages in Gastric Cancer: Pathogenesis, Interactions, and Therapeutic Implications
    Wu, Zhenxing
    Xia, Qingqing
    Huang, Huifeng
    JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS, 2023, 37 (10): : 5069 - 5079
  • [2] Tumor-Associated Mast Cells in Urothelial Bladder Cancer: Optimizing Immuno-Oncology
    Choi, Hae Woong
    Naskar, Manisha
    Seo, Ho Kyung
    Lee, Hye Won
    BIOMEDICINES, 2021, 9 (11)
  • [3] Tumor-Associated Macrophages-Implications for Molecular Oncology and Imaging
    Kimm, Melanie A.
    Klenk, Christopher
    Alunni-Fabbroni, Marianna
    Kaestle, Sophia
    Stechele, Matthias
    Ricke, Jens
    Eisenblaetter, Michel
    Wildgruber, Moritz
    BIOMEDICINES, 2021, 9 (04)
  • [4] Hallmarks of sex bias in immuno-oncology: mechanisms and therapeutic implications
    Xiao, Tong
    Lee, Juyeun
    Gauntner, Timothy D.
    Velegraki, Maria
    Lathia, Justin D.
    Li, Zihai
    NATURE REVIEWS CANCER, 2024, 24 (05) : 338 - 355
  • [5] Post-Translational Modifications in Tumor-Associated Antigens as a Platform for Novel Immuno-Oncology Therapies
    Srivastava, Anurag Kumar
    Guadagnin, Giorgia
    Cappello, Paola
    Novelli, Francesco
    CANCERS, 2023, 15 (01)
  • [6] Roles of tumor-associated macrophages in tumor progression: implications on therapeutic strategies
    Zhu, Shangli
    Yi, Ming
    Wu, Yuze
    Dong, Bing
    Wu, Kongming
    EXPERIMENTAL HEMATOLOGY & ONCOLOGY, 2021, 10 (01)
  • [7] Roles of tumor-associated macrophages in tumor progression: implications on therapeutic strategies
    Shuangli Zhu
    Ming Yi
    Yuze Wu
    Bing Dong
    Kongming Wu
    Experimental Hematology & Oncology, 10
  • [8] The role of tumor-associated macrophages in osteosarcoma progression - therapeutic implications
    Huang, Qingshan
    Liang, Xin
    Ren, Tingting
    Huang, Yi
    Zhang, Hongliang
    Yu, Yiyang
    Chen, Chenglong
    Wang, Wei
    Niu, Jianfang
    Lou, Jingbing
    Guo, Wei
    CELLULAR ONCOLOGY, 2021, 44 (03) : 525 - 539
  • [9] Tumor-associated macrophages: role in cancer development and therapeutic implications
    Arash Salmaninejad
    Saeed Farajzadeh Valilou
    Arash Soltani
    Sepideh Ahmadi
    Yousef Jafari Abarghan
    Rhonda J. Rosengren
    Amirhossein Sahebkar
    Cellular Oncology, 2019, 42 : 591 - 608
  • [10] The role of tumor-associated macrophages in osteosarcoma progression – therapeutic implications
    Qingshan Huang
    Xin Liang
    Tingting Ren
    Yi Huang
    Hongliang Zhang
    Yiyang Yu
    Chenglong Chen
    Wei Wang
    Jianfang Niu
    Jingbing Lou
    Wei Guo
    Cellular Oncology, 2021, 44 : 525 - 539