Triterpenoids from the rhizomes and roots of Gentiana scabra Bge. and their cytotoxic activities

被引：0

作者：

Liu, Guan-Ke ^{[1
,2
]}

Zhang, Bing-Yang ^{[1
]}

Niu, Zheng ^{[1
,2
]}

Chen, Jia-Qi ^{[1
,2
]}

Fan, Chun-Yu ^{[1
,2
]}

Deng, Xin-Yue ^{[1
,2
]}

Ye, Fan-Qing ^{[1
,2
]}

Cao, Shi-Jie ^{[2
]}

Kang, Ning ^{[3
]}

Yao, Tie ^{[2
]}

Qiu, Feng ^{[1
,2
]}

机构：

[1] Tianjin Univ Tradit Chinese Med, Sch Chinese Mat Med, Tianjin Key Lab Therapeut Subst Tradit Chinese Med, Tianjin 301617, Peoples R China

[2] Tianjin Univ Tradit Chinese Med, State Key Lab Component Based Chinese Med, Tianjin 301617, Peoples R China

[3] Tianjin Univ Tradit Chinese Med, Sch Med Technol, Tianjin 301617, Peoples R China

来源：

FITOTERAPIA | 2025年 / 180卷

基金：

中国国家自然科学基金;

关键词：

Gentiana scabra Bge; Pentacyclic triterpenoids; Cytotoxicity; 3,4seco; PENTACYCLIC TRITERPENOIDS; GENTIOPICROSIDE; CANCER; LEAVES;

D O I：

10.1016/j.fitote.2024.106268

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Phytochemical investigation on the rhizomes and roots of Gentiana scabra (Gentianaceae) led to the isolation of five new triterpenoids (1-5), together with seven known ones (6-12). The structures and absolute configurations of the new compounds were elucidated by spectroscopic data interpretation, ECD calculation and X-ray crystallographic analysis. Noticeably, compound 4 was an uncommon 3,4-seco-pentacyclic triterpenoid in natural products. The in vitro cytotoxic activities of all isolates against human cancer cell lines (HepG2, Hep3B, HCT116, and U87) were measured using MTT assay. Among them, compounds 2 - 9 , 11 , and 12 exhibited anti-proliferative effects against these tumor cell lines.

引用

页数：7

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