Unlocking transcription-coupled DNA repair with the STK19 key

被引:0
|
作者
Kuper, Jochen [1 ]
Kisker, Caroline [1 ]
Van Houten, Bennett [2 ,3 ]
机构
[1] Univ Wurzburg, Rudolf Virchow Ctr Integrat & Translat Bioimaging, Wurzburg, Germany
[2] Univ Pittsburgh, Sch Med, Dept Pharmacol & Chem Biol, Pittsburgh, PA 15213 USA
[3] UPMC, Hillman Canc Ctr, Pittsburgh, PA 15213 USA
关键词
REMOVAL; DAMAGE;
D O I
10.1016/j.molcel.2024.11.027
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A study in Molecular Cell by Ramadhin et al.1 and two studies in Cell by van den Heuvel et al.2 and by Mevissen et al.3 show that STK19 is a key protein in transcription-coupled nucleotide excision repair (TC-NER) in mammalian cells by mediating the initial repair protein complex formation and subsequent TFIIH recruitment, thereby enabling the vital damage verification step.
引用
收藏
页码:4693 / 4695
页数:3
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