Unlocking transcription-coupled DNA repair with the STK19 key

被引：0

作者：

Kuper, Jochen ^{[1
]}

Kisker, Caroline ^{[1
]}

Van Houten, Bennett ^{[2
,3
]}

机构：

[1] Univ Wurzburg, Rudolf Virchow Ctr Integrat & Translat Bioimaging, Wurzburg, Germany

[2] Univ Pittsburgh, Sch Med, Dept Pharmacol & Chem Biol, Pittsburgh, PA 15213 USA

[3] UPMC, Hillman Canc Ctr, Pittsburgh, PA 15213 USA

来源：

MOLECULAR CELL | 2024年 / 84卷 / 24期

关键词：

REMOVAL; DAMAGE;

D O I：

10.1016/j.molcel.2024.11.027

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A study in Molecular Cell by Ramadhin et al.1 and two studies in Cell by van den Heuvel et al.2 and by Mevissen et al.3 show that STK19 is a key protein in transcription-coupled nucleotide excision repair (TC-NER) in mammalian cells by mediating the initial repair protein complex formation and subsequent TFIIH recruitment, thereby enabling the vital damage verification step.

引用

页码：4693 / 4695

页数：3

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