Aging affects the mouse brain in a region-specific manner

被引：0
|
作者：
Cai, Ling [1 ,2 ]
Zhang, Yueman [1 ,2 ]
Zhou, Yuxi [1 ,2 ]
Wang, Xin [1 ,2 ]
机构：
[1] Shanghai Jiao Tong Univ, Renji Hosp, Dept Anesthesiol, Sch Med, Shanghai 200127, Peoples R China
[2] Shanghai Jiao Tong Univ, Key Lab Anesthesiol, Minist Educ, Pujian Rd 160, Shanghai 200120, Peoples R China
来源：
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 2025年 / 45卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Aging; cognitive decline; brain region; white matter; microglia; MICROGLIA;
D O I：
10.1177/0271678X241289780
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Aging-related cognitive decline is emerging as a health concern during the aging process of the global population. Hahn and colleagues found that glial aging was particularly accelerated in white matter compared to cortical regions. Specialized neuronal populations showed region-specific changes in gene expression. Acute dietary restriction triggers a reprogramming of genes associated with the circadian clock in glial cells, whereas injections of young mouse plasma selectively reverse age-related expression patterns. The discovery of region-specific aging could enhance our understanding of the aging process and offer new possibilities for innovative treatment strategies and interventions for cognitive impairments related to aging.
引用
收藏
页码：373 / 375
页数：3
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