Nickel-Catalyzed Enantioselective Reductive Spirocyclization of 1,6-Enynes with o -Bromobenzaldehydes

被引：0
|
作者：
Guo, Haoyun [1 ]
Chen, Yate [2 ]
Kong, Wangqing [1 ]
机构：
[1] Wuhan Univ, Inst Adv Studies IAS, Wuhan 430072, Peoples R China
[2] Huazhong Agr Univ, Coll Chem, Wuhan 430070, Peoples R China
来源：
SYNTHESIS-STUTTGART | 2025年 / 57卷 / 08期
基金：
中国国家自然科学基金;
关键词：
nickel catalysis; enantioselectivity; reductive spirocyclization; 1,6-enynes; spiroindanones; COUPLING REACTIONS; SPIRO COMPOUNDS; CYCLIZATION; HALIDES; NOMENCLATURE;
D O I：
10.1055/a-2456-9530
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We developed a Ni-catalyzed asymmetric reductive spirocyclization of 1,6-enynes with o-haloaryl aldehydes. This approach provides an efficient method for the construction of chiral spiroindanone pyrrolidine derivatives in good yields with excellent enantio- and diastereoselectivity (up to 99% ee, >20:1 dr). This reaction does not require pre-prepared organometallic reagents and exhibits excellent substrate compatibility.
引用
收藏
页码：1448 / 1456
页数：9
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