High glucose induces senescence in synovial mesenchymal stem cells through mitochondrial dysfunction

被引:0
|
作者
Shuyi Tan [1 ]
Wangxi Wu [1 ]
Yifan Chen [1 ]
Hai Gao [1 ]
机构
[1] Southern Medical University,Stomatological Hospital, School of Stomatology
关键词
High glucose; Senescence; SMSCs; Mitochondrial dysfunction; OA;
D O I
10.1186/s12903-025-05938-y
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 50 条
  • [41] Human synovial cells as a source of mesenchymal stem cells and pluripotent stem cells
    Kim, M-J
    Chang, J-S
    Han, Y-M
    Cho, Y. S.
    FEBS JOURNAL, 2012, 279 : 189 - 189
  • [42] High glucose induces mitochondrial dysfunction independently of protein O-GlcNAcylation
    Dassanayaka, Sujith
    Readnower, Ryan D.
    Salabei, Joshua K.
    Long, Bethany W.
    Aird, Allison L.
    Zheng, Yu-Ting
    Muthusamy, Senthilkumar
    Facundo, Heberty T.
    Hill, Bradford G.
    Jones, Steven P.
    BIOCHEMICAL JOURNAL, 2015, 467 : 115 - 126
  • [43] Role of Lysosomal Acidification Dysfunction in Mesenchymal Stem Cell Senescence
    Zhang, Weijun
    Bai, Jinwu
    Hang, Kai
    Xu, Jianxiang
    Zhou, Chengwei
    Li, Lijun
    Wang, Zhongxiang
    Wang, Yibo
    Wang, Kanbin
    Xue, Deting
    FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2022, 10
  • [44] Estrogen Signaling Induces Mitochondrial Dysfunction-Associated Autophagy and Senescence in Breast Cancer Cells
    Bajbouj, Khuloud
    Shafarin, Jasmin
    Taneera, Jalal
    Hamad, Mawieh
    BIOLOGY-BASEL, 2020, 9 (04): : 1 - 14
  • [45] Hypoxia induces senescence of bone marrow mesenchymal stem cells via altered gut microbiota
    Junyue Xing
    Yongquan Ying
    Chenxi Mao
    Yiwei Liu
    Tingting Wang
    Qian Zhao
    Xiaoling Zhang
    Fuxia Yan
    Hao Zhang
    Nature Communications, 9
  • [46] Hypoxia induces senescence of bone marrow mesenchymal stem cells via altered gut microbiota
    Xing, Junyue
    Ying, Yongquan
    Mao, Chenxi
    Liu, Yiwei
    Wang, Tingting
    Zhao, Qian
    Zhang, Xiaoling
    Yan, Fuxia
    Zhang, Hao
    NATURE COMMUNICATIONS, 2018, 9
  • [47] High glucose and high lipid induced mitochondrial dysfunction in JEG-3 cells through oxidative stress
    Duan, Yang
    Sun, Fuqiang
    Li, Yueqin
    Yang, Suyan
    OPEN LIFE SCIENCES, 2023, 18 (01):
  • [48] miR-486-5p Induces Replicative Senescence of Human Adipose Tissue-Derived Mesenchymal Stem Cells and Its Expression Is Controlled by High Glucose
    Kim, Yeon Jeong
    Hwang, Soo Hyun
    Lee, Sun Young
    Shin, Keun Koo
    Cho, Hyun Hwa
    Bae, Yong Chan
    Jung, Jin Sup
    STEM CELLS AND DEVELOPMENT, 2012, 21 (10) : 1749 - 1760
  • [49] Loss of the histone methyltransferase Ezh2 induces cellular senescence in mesenchymal stem cells
    Dudakovic, Amel
    Galeano-Garces, Catalina
    Paradise, Christopher
    Galeano-Garces, Daniela
    Khani, Farzaneh
    Thaler, Roman
    Van Wijnen, Andre
    JOURNAL OF BONE AND MINERAL RESEARCH, 2018, 33 : 364 - 365
  • [50] High glucose induces early senescence in adipose-derived stem cells by accelerating p16 and mTOR
    Hieu Liem Pham
    Phuc Van Pham
    BIOMEDICAL RESEARCH AND THERAPY, 2019, 6 (06): : 3213 - 3221