Effect of diabetes mellitus on 3-year outcomes in patients with acute myocardial infarction with nonobstructive arteries

Background: Diabetes mellitus (DM) is a significant factor in increased mortality rates among patients with acute myocardial infarction (AMI), but research on its impact on the long-term outcomes in patients with MI with nonobstructive coronary arteries (MINOCA) is limited. Thus, a comparison of the 3-year clinical outcomes between the DM and non-DM groups among patients with MINOCA was undertaken. Methods: From the Korea AMI Registry-National Institute of Health dataset, 13,104 AMI patients were enrolled. After applying the exclusion criteria, 379 patients with MINOCA were included. The primary clinical outcomes were major adverse cardiac and cerebrovascular events (MACCE), de- fined as all-cause death, recurrent myocardial infarction (MI), repeat coronary revascularization, and stroke. The secondary outcomes were the individual components of MACCE. Results: The adjusted hazard ratios for 3-year MACCE (2.287, p = 0.010), all-cause death (2.845, p = 0.004), and non-cardiac death (non-CD, 3.914, p = 0.008) were higher in the DMgroup than in the non-DMgroup. It is speculated that the higher non-CD rate in the MINOCA group is attributable to a higher proportion of patients with non-ST-segment elevation MI in the total study population. The CD, recurrent MI, revascularization, and stroke rates were similar between the DM and non-DM groups. DM, advanced age, cardiopulmonary resuscitation on admission, and nonuse of statin medications were significant predictors of MACCE. Conclusions: In this study involving patients with MINOCA, the DMgroup exhibited a higher 3-year mortality rate than the non-DMgroup. Thus, DMdemonstrated a hazardous effect even inpatients with MINOCA. (Cardiol J 2024; 31, 5: 675-689)