Bone marrow immune cells and drug resistance in acute myeloid leukemia

被引：0

作者：

Zhang, Miao ^{[1
,2
]}

Yang, You ^{[1
,2
]}

Liu, Jing ^{[1
,2
]}

Guo, Ling ^{[1
,2
]}

Guo, Qulian ^{[1
,2
]}

Liu, Wenjun ^{[1
,2
]}

机构：

[1] Southwest Med Univ, Affiliated Hosp, Dept Pediat Hematol Oncol, Children Hematol Oncol & Birth Defects Lab, Luzhou, Sichuan, Peoples R China

[2] Southwest Med Univ, Sichuan Clin Res Ctr Birth Defects, Affiliated Hosp, Luzhou, Sichuan, Peoples R China

来源：

EXPERIMENTAL BIOLOGY AND MEDICINE | 2025年 / 250卷

关键词：

leukemia; immune cells; drug resistance; bone marrow; immunosuppressive microenvironment; REGULATORY T-CELLS; SUPPRESSOR-CELLS; DENDRITIC CELLS; POOR-PROGNOSIS; NK CELLS; AML CELLS; IN-VITRO; EXPRESSION; ACTIVATION; INDUCTION;

D O I：

10.3389/ebm.2025.10235

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

In recent years, the relationship between the immunosuppressive niche of the bone marrow and therapy resistance in acute myeloid leukemia (AML) has become a research focus. The abnormal number and function of immunosuppressive cells, including regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs), along with the dysfunction and exhaustion of immunological effector cells, including cytotoxic T lymphocytes (CTLs), dendritic cells (DCs) and natural killer cells (NKs), can induce immune escape of leukemia cells and are closely linked to therapy resistance in leukemia. This article reviews the research progress on the relationship between immune cells in the marrow microenvironment and chemoresistance in AML, aiming to provide new ideas for the immunotherapy of AML.

引用

页数：17

共 50 条

[41] BONE-MARROW TRANSPLANTATION AND ACUTE MYELOID-LEUKEMIA
FERRANT, A
VERNANT, JP
BONE MARROW TRANSPLANTATION, 1993, 12 : S34 - S36
[42] Identification of Acute Myeloid Leukemia Bone Marrow Circulating MicroRNAs
Agha, Douaa Moussa
Rouas, Redouane
Najar, Mehdi
Bouhtit, Fatima
Naamane, Najib
Fayyad-Kazan, Hussein
Bron, Dominique
Meuleman, Nathalie
Lewalle, Philippe
Merimi, Makram
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (19)
[43] BONE-MARROW TRANSPLANTATION FOR ACUTE MYELOID-LEUKEMIA
POWLES, RL
LYON MEDICAL, 1981, 246 (16): : 235 - 236
[44] Significance of Bone Marrow Histology in the Diagnosis of Acute Myeloid Leukemia
Younus, Usman
Saba, Kanwal
Aijaz, Javeria
Bukhari, Mulazim Hussain
Naeem, Samina
ANNALS OF KING EDWARD MEDICAL UNIVERSITY LAHORE PAKISTAN, 2011, 17 (01): : 5 - 8
[45] Outcomes of patients with acute myeloid leukemia and bone marrow fibrosis
Urrutia, Samuel
Kantarjian, Hagop M.
Ravandi-Kashani, Farhad
Bueso-Ramos, Carlos
Kanagal-Shamanna, Rashmi
Jabbour, Elias
Montalban-Bravo, Guillermo
Short, Nicholas J.
Daver, Naval
Borthakur, Gautam
Dinardo, Courtney D.
Kadia, Tapan M.
Masarova, Lucia
Bose, Prithviraj
Pemmaraju, Naveen
Garcia-Manero, Guillermo
Sasaki, Koji
JOURNAL OF HEMATOLOGY & ONCOLOGY, 2024, 17 (01)
[46] BONE-MARROW TRANSPLANTATION IN ACUTE MYELOID-LEUKEMIA
MANDELLI, F
EXPERIMENTAL HEMATOLOGY, 1991, 19 (06) : 463 - 463
[47] The immunometabolic landscape of the bone marrow microenvironment in acute myeloid leukemia
Binyan Xu
Ziying Zhou
Yueting Wen
Zhongwei Li
Zhongxi Huang
Yuhua Li
Experimental Hematology & Oncology, 11
[48] Hypocellular acute myeloid leukemia treated with bone marrow transplantation
Keino, Dai
Kondoh, Kensuke
Ohyama, Ryo
Morimoto, Mizuho
Mori, Tetsuya
Ito, Masafumi
Kinoshita, Akitoshi
PEDIATRICS INTERNATIONAL, 2017, 59 (04) : 490 - 493
[49] BONE-MARROW TRANSPLANTATION FOR ACUTE MYELOID-LEUKEMIA
HAMILTON, CR
BARRETT, A
POWLES, R
BRITISH JOURNAL OF CANCER, 1988, 58 (04) : 527 - 528
[50] Bone marrow hyaluronan distribution in patients with acute myeloid leukemia
Gunnel Sundström
Inger Marie S. Dahl
Magnus Hultdin
Berith Lundström
Anders Wahlin
Anna Engström-Laurent
Medical Oncology, 2005, 22 : 71 - 78

← 1 2 3 4 5 →