Inhibitory Effect of Hemin - Poly(3-hydroxybutyrate) System on E. coli and S. aureus Growth

被引：1

作者：

Gruznov, Dmitry, V ^{[1
]}

Gruznova, Olga A. ^{[2
]}

Popov, Nikolay I. ^{[1
]}

Alieva, Zoya E. ^{[1
]}

Stepanova, Svetlana P. ^{[1
]}

Shcherbakova, Gulizar Sh. ^{[1
]}

V. Kitushina, Ekaterina ^{[3
,4
]}

Tyubaeva, Polina M. ^{[3
,5
]}

Varyan, Ivetta A. ^{[3
,5
]}

Olkhov, Anatoly A. ^{[2
,3
,5
]}

Popov, Anatoly A. ^{[3
,5
]}

Klimenko, Inna, V ^{[3
]}

Lobanov, Anton, V ^{[2
,3
,4
,5
]}

机构：

[1] RAS, All Russian Res Inst Vet Sanitat Hyg & Ecol, Branch Fed Sci Ctr KI Skryabin, Ya R Kovalenko All Russian Res Inst Expt Vet Med, Moscow 123022, Russia

[2] RAS, NN Semenov Fed Res Ctr Chem Phys, Moscow 119991, Russia

[3] RAS, NM Emanuel Inst Biochem Phys, Moscow 119334, Russia

[4] Moscow Pedag State Univ, Moscow 119991, Russia

[5] GV Plekhanov Russian Univ Econ, Moscow 117997, Russia

来源：

MACROHETEROCYCLES | 2023年 / 16卷 / 04期

基金：

俄罗斯科学基金会;

关键词：

Hemin; poly(3-hydroxybutyrate); Escherichia coli; Staphylococcus aureus; inhibitory effect; IN-VITRO; IRON; COMPLEX; ZINC;

D O I：

10.6060/mhc235386g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The preparation method of porphyrin-polymer system -hemin-poly(3-hydroxybutyrate) (hemin-PHB) and its inhibitory effect on the growth of Gram-negative and Gram-positive microorganisms -Escherichia coli and Staphylococcus aureus, which are the common cause of wound infections, are presented. The assessment of antimicrobial activity was carried out by measuring of the inhibition zone diameters after bacterial daily incubation. It was shown that hemin-PHB efficiency was directly related to the hemin concentration. Thus, PHB containing 5% hemin (wt. %) inhibited E. coli and S. aureus significantly. The obtained porphyrin-polymer system can be recommended for use as the antiseptic material for wound treatment.

引用

页数：67

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