Fibrolamellar hepatocellular carcinoma with intrapancreatic nodal metastases masquerading as pancreatic neuroendocrine tumour with hepatic metastases

被引:0
|
作者
Paladugu, Sree Vani [1 ]
Raypattanaik, Niladri Mohan [1 ]
Mitra, Suvradeep [2 ]
Kaman, Lileswar [1 ]
机构
[1] Post Grad Inst Med Educ & Res, Gen Surg, Chandigarh, India
[2] PGIMER, Histopathol, Chandigarh, India
关键词
Pathology; Surgery; Immunohistochemistry; Pancreas and biliary tract; Liver disease;
D O I
10.1136/bcr-2024-262872
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Fibrolamellar hepatocellular carcinoma (FL-HCC) is a primary liver tumour presenting at a young age. Aggressive surgery of FL-HCC is the mainstay of management unlike other malignancies where metastatic stage precludes curative surgery. There are limited reports of response of FL-HCC to systemic therapies predominantly owing to its rarity. In the index case, a young boy presented with the awareness of abdominal lump with minimal systemic complaints. Radiological imaging showed arterially enhancing liver and pancreatic lesions leading to clinical suspicion of non-functional pancreatic neuroendocrine tumour with neuroendocrine liver metastases in non-cirrhotic liver. Histopathological examination with immunohistochemistry following left lateral hepatectomy with pancreaticoduodenectomy and lymphadenectomy showed FL-HCC with lymph nodal metastases involving intrapancreatic lymph node and station 7, 8 lymph nodes. The patient had an uneventful postsurgical recovery and was kept under close follow-up. FL-HCC with nodal metastasis involving intrapancreatic lymph node is an unusual phenomenon and a challenging clinicopathological diagnosis
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页数:5
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