New alkylamides from the pericarps of Zanthoxylum schinifolium

被引:0
|
作者
Xu, Jia-Xin [1 ,2 ]
Lin, Li-Wu [2 ]
He, Min [2 ]
Peng, Xing-Rong [2 ]
Zhang, Zun-Ting [1 ]
Qiu, Ming-Hua [2 ]
机构
[1] Shaanxi Normal Univ, Sch Chem & Chem Engn, Xian 710119, Peoples R China
[2] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochemistry & Plant Resources Wes, Kunming 650201, Peoples R China
基金
中国国家自然科学基金;
关键词
Rutaceae; Zanthoxylum schinifolium; Alkylamides; Neuroprotective activity; ISOBUTYLHYDROXYAMIDES; AMIDES;
D O I
10.1016/j.fitote.2024.106057
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
The pericarps of Zanthoxylum schinifolium Sieb. et Zucc were called "green huajiao", which were used as traditional folk medicine and popular seasoning in China. In this study, twenty-seven alkylamides, including a rare alkylamide containing two amide groups (1), an alkylamide with a furan ring (5), six new alkylamide analogues (2-4, 6 - 8 ), together with nineteen known alkylamides (9-27) were isolated from green huajiao. Their structures were elucidated by extensive spectroscopic analysis, including 1D, 2D NMR, HRESIMS, and UV spectra. Furthermore, compounds 5 , 18 , 21 , and 22 exhibited weak protective activity for corticosterone-induced PC12 cells damage.
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页数:7
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