The role of tranexamic acid for infection prevention after fracture fixation

被引:0
|
作者
Benjumea-Carrasco, Antonio [1 ]
Guembe, Maria [2 ,3 ]
Diaz-Navarro, Marta [2 ,3 ]
Munoz, Patricia [2 ,3 ,4 ,5 ]
Vaquero-Martin, Javier [1 ,5 ]
Chana-Rodriguez, Francisco [6 ]
机构
[1] Hosp Gen Univ Gregorio Maranon, Dept Orthopaed Surg & Traumatol, Madrid, Spain
[2] Hosp Gen Univ Gregorio Maranon, Dept Clin Microbiol & Infect Dis, Madrid, Spain
[3] Inst Invest Sanitaria Gregorio Maranon, Madrid, Spain
[4] CIBER Enfermedades Resp CIBERES CB06 06 0058, Madrid, Spain
[5] Univ Complutense Madrid, Sch Med, Madrid, Spain
[6] Rashid Hosp, Trauma Dept, Dubai, U Arab Emirates
来源
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED | 2024年 / 55卷
关键词
Tranexamic Acid; Fracture infection; Infection prevention; Biofilm formation; Wound complications; TOTAL KNEE ARTHROPLASTY; PERIPROSTHETIC JOINT INFECTION; REDUCING BLOOD-LOSS; TOTAL HIP; TRANSFUSION; REVISION; SURGERY; TRAUMA; SAFETY; REPLACEMENT;
D O I
暂无
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Despite the measures employed, fracture-related infections remain a concern after fracture fixation worldwide. Recently, the role of tranexamic acid as a protective drug against postsurgical infections in joint replacement and orthopedic trauma surgery has been proposed, where tranexamic acid has been associated with less surgical wounds complications and infectious complications including periprosthetic joint infection. The mechanism through which tranexamic acid exerts a protective effect against peri-implant infection is still the subject of debate. Although some authors hypothesize an indirect effect inhibiting the formation of postoperative hematoma, there are several studies that show a direct antibacterial effect of the drug against the capacity of bacterial aggregation, even avoiding biofilm formation, favoring the immune response of the host and the action of antibiotics. The purpose of this narrative review is to show the current role of tranexamic acid in orthopedic trauma, specifically its relationship with the prevention of infections related to implants.
引用
收藏
页数:4
相关论文
共 50 条
  • [31] The efficacy of intravenous tranexamic acid administration at induction in definitive hip fracture surgery: Is there a role?
    Kanthasamy, S.
    Guhan, B.
    Chakravarty, D.
    Parker, Martyn J.
    INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED, 2021, 52 (08): : 2361 - 2366
  • [32] APPLICATION OF TRANEXAMIC ACID INTRAVENOUS DRIP BEFORE INTERNAL FIXATION IN THE TREATMENT OF ELDERLY PATIENTS WITH UNSTABLE INTERTROCHANTERIC FRACTURE
    Huang, Shufeng
    Hu, Wenlin
    Shen, Zheyuan
    Wang, Minli
    ACTA MEDICA MEDITERRANEA, 2021, 37 (02): : 1183 - 1187
  • [33] Tranexamic acid for the prevention and treatment of postpartum haemorrhage
    Sentithes, L.
    Lasocki, S.
    Ducloy-Bouthors, A. S.
    Deruelle, P.
    Dreyfus, M.
    Perrotin, F.
    Goffinet, F.
    Deneux-Tharaux, C.
    BRITISH JOURNAL OF ANAESTHESIA, 2015, 114 (04) : 576 - 587
  • [34] Tranexamic acid administration for the prevention of periprosthetic joint infection and surgical site infection: a systematic review and meta-analysis
    Imanishi, Keiji
    Kobayashi, Naomi
    Kamono, Emi
    Yukizawa, Yohei
    Takagawa, Shu
    Choe, Hyonmin
    Kumagai, Ken
    Inaba, Yutaka
    ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY, 2023, 143 (11) : 6883 - 6899
  • [35] Factors related to infection after fixation in the process of late healed bone fracture
    Zhang, Xiaoming
    Zhan, Xuebin
    Zou, Peng
    An, Huixia
    EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2017, 14 (02) : 1126 - 1130
  • [36] Arthroscopic debridement for infection after fracture fixation (IAFF) of the ankle: A case report
    Wiratnaya, I. Gede Eka
    Nugraha, Hans Kristian
    Kawiyana, I. Ketut Siki
    Subawa, I. Wayan
    Sutheno, Andrew
    INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS, 2022, 91
  • [37] Infection after fracture fixation of the tibia: Analysis of healthcare utilization and related costs
    Metsemakers, Willem-Jan
    Smeets, Bart
    Nijs, Stefaan
    Hoekstra, Harm
    INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED, 2017, 48 (06): : 1204 - 1210
  • [38] Tranexamic acid administration for the prevention of periprosthetic joint infection and surgical site infection: a systematic review and meta-analysis
    Keiji Imanishi
    Naomi Kobayashi
    Emi Kamono
    Yohei Yukizawa
    Shu Takagawa
    Hyonmin Choe
    Ken Kumagai
    Yutaka Inaba
    Archives of Orthopaedic and Trauma Surgery, 2023, 143 : 6883 - 6899
  • [39] Incidence and Risk Factors of Infection After Fracture Fixation: A Multicenter Cohort Study
    Wang, Baisheng
    Zhang, Jingdong
    Han, Wenfeng
    Tang, Xin
    Tian, Feng
    ORTHOPAEDIC SURGERY, 2024,
  • [40] Maintenance of Hardware After Early Postoperative Infection Following Fracture Internal Fixation
    Berkes, Marschall
    Obremskey, William T.
    Scannell, Brian
    Ellington, Kent
    Hymes, Robert A.
    Bosse, Michael
    JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 2010, 92A (04): : 823 - 828