Synthesis of Novel 4-FluorophenylSubstituted Carbocyclic and Heterocyclic Compounds

被引：0

作者：

Bobrov, Pavel S. ^{[1
]}

Olchev, Daniil A. ^{[1
]}

Vishnyakova, Ekaterina E. ^{[1
]}

Suboch, Georgii A. ^{[1
]}

机构：

[1] Reshetnev Siberian State Univ Sci & Technol, Krasnoyarsk, Russia

来源：

JOURNAL OF SIBERIAN FEDERAL UNIVERSITY-CHEMISTRY | 2025年 / 18卷 / 01期

关键词：

aminopyrazole; nitrosoaniline; nitrosopyrazole; cyclocondensation; fluorine-substituted; diketone; DERIVATIVES;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We demonstrated the first synthesis of 2-hydroxyimino-1-(4-fluorophenyl)butane-1,3-dione by nitrosation of 1-(4-fluorophenyl)butane-1,3-dione with sodium nitrite in acetic acid. The three- component reaction of 2-hydroxyamino-1-(4-fluorophenyl)butane-1,3-dione with acetone and aliphatic dialkylamines (diethylamine or diethanolamine) leads to new N, N-dialkyl-3-methyl-4-nitroso-5-(4-fluorophenyl) anilines. Cyclocondensation of 2-hydroxyimino-1-(4-fluorophenyl)butane-1,3-dione with hydrazine hydrate leads to 3-methyl-4-nitroso-5-(4-fluorophenyl)-1H-pyrazole. Reduction of nitrosopyrazole gives the corresponding fluoro- substituted aminopyrazole. The synthesized compounds were characterized by IR, NMR, UV-Vis, and MS.

引用

页码：34 / 40

页数：7

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