Gene Editing: An Effective Tool for the Future Treatment of Kidney Disease

被引:0
|
作者
Cao, Mei-Ling [1 ]
Han, Rui-Yi [2 ]
Chen, Si-Da [3 ]
Zhao, Dan-Yang [2 ]
Shi, Ming-Yue [2 ]
Zou, Jia-Hui [2 ]
Li, Lei [3 ]
Jiang, Hong-Kun [2 ]
机构
[1] China Med Univ, Hosp 1, Dept Neonatol, Shenyang 110001, Liaoning, Peoples R China
[2] China Med Univ, Hosp 1, Dept Pediat, 155 Nanjing North St, Shenyang 110001, Liaoning, Peoples R China
[3] China Med Univ, Shengjing Hosp, Dept Orthopaed Surg, 36 Sanhao St, Shenyang 110004, Liaoning, Peoples R China
关键词
clear cell renal cell carcinoma; ccRCC; clustered regularly interspaced short palindromic repeats; CRISPR; gene editing; genetic kidney diseases; polycystic kidney disease; IN-VIVO; DNA; CRISPR-CAS9; CELL; EXPRESSION; PROTEIN; BASE; ACTIVATION; SYSTEM; STEM;
D O I
10.2147/JIR.S506760
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Gene editing technology involves modifying target genes to alter genetic traits and generate new phenotypes. Beginning with zinc-finger nucleases (ZFN) and transcription activator-like effector nucleases (TALEN), the field has evolved through the advent of clustered regularly interspaced short palindromic repeats and CRISPR-associated protein (CRISPR-Cas) systems, and more recently to base editors (BE) and prime editors (PE). These innovations have provided deep insights into the molecular mechanisms of complex biological processes and have paved the way for novel therapeutic strategies for a range of diseases. Gene editing is now being applied in the treatment of both genetic and acquired kidney diseases, as well as in kidney transplantation and the correction of genetic mutations. This review explores the current applications of mainstream gene editing technologies in biology, with a particular emphasis on their roles in kidney disease research and treatment of. It also addresses the limitations and challenges associated with these technologies, while offering perspectives on their future potential in this field.
引用
收藏
页码:4001 / 4018
页数:18
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