High-Pressure Reactor Technology for Aerated Biotransformations

被引：0

作者：

Niehaus, Daniel ^{[1
]}

Lyberis, Anastasios ^{[2
]}

Houssaini, Selma Iraqi ^{[1
]}

Percin, Zeynep ^{[2
]}

Liebsch, Gregor ^{[3
]}

Bubenheim, Paul ^{[2
]}

Hoffmann, Marko ^{[1
]}

Liese, Andreas ^{[2
]}

Schlueter, Michael ^{[1
]}

机构：

[1] Hamburg Univ Technol, Inst Multiphase Flows, Eissendorfer Str 38, D-21073 Hamburg, Germany

[2] Hamburg Univ Technol, Inst Tech Biocatalysis, Denickestr 15, D-21073 Hamburg, Germany

[3] PreSens Precis Sensing GmbH, BioPk 11, D-93053 Regensburg, Germany

来源：

CHEMICAL ENGINEERING & TECHNOLOGY | 2025年 / 48卷 / 01期

关键词：

Aerated biotechnological reactor; Glucose oxidase; High pressure; Optical oxygen measurement; Process intensification; BUBBLE-COLUMNS; MASS-TRANSFER; TEMPERATURE; PH; INACTIVATION; STABILITY; KINETICS;

D O I：

10.1002/ceat.202400043

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

Utilizing pressure as a process parameter can make biotechnological processes more efficient and attractive compared to established ones. This paper presents a high-pressure reactor setup for enzymatically catalyzed gas-liquid reactions, which can be operated up to 15.0 MPa. The reactor is equipped with optical measurement technology for inline and in situ monitoring of the oxygen concentration under high-pressure conditions. The setup is characterized by assessing the influence of the process parameter pressure on the conversion of the glucose oxidation to d-glucono-delta-lactone by immobilized glucose oxidase. The study demonstrates that the increased oxygen availability due to higher solubility reduces the reaction time in a batch reactor from 270 to 90 min.

引用

页数：10

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