MRI analysis of relative tumor enhancement in liver metastases and correlation with immunohistochemical features

被引:0
|
作者
Ordonez, Felix Barajas [1 ,2 ]
Gottschling, Sebastian [1 ]
Eger, Kai Ina [3 ]
Borggrefe, Jan [4 ]
Jechorek, Doerthe [3 ]
Surov, Alexey [1 ,4 ]
机构
[1] Otto von Guericke Univ, Univ Clin Radiol & Nucl Med, Magdeburg, Germany
[2] Univ Hosp RWTH, Dept Diagnost & Intervent Radiol, Aachen, Germany
[3] Otto von Guericke Univ, Inst Pathol, Magdeburg, Germany
[4] Ruhr Univ Bochum, Johannes Wesling Univ, Inst Radiol Neuroradiol & Nucl Med, Minden, Germany
来源
INSIGHTS INTO IMAGING | 2024年 / 15卷 / 01期
关键词
Magnetic resonance imaging; Immunohistochemistry; Breast cancer; Pancreas cancer; Colorectal cancer;
D O I
10.1186/s13244-024-01866-7
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
ObjectiveInvestigate the association between the relative tumor enhancement (RTE) of gadoxetic acid across various MRI phases and immunohistochemical (IHC) features in patients with liver metastases (LM) from colorectal cancer (CRC), breast cancer (BC), and pancreatic cancer (PC).MethodsA retrospective analysis was conducted on 68 patients with LM who underwent 1.5-T MRI scans. Non-contrast and contrast-enhanced T1-weighted (T1-w) gradient echo (GRE) sequences were acquired before LM biopsy. RTE values among LM groups were compared by cancer type using analysis of variance. The relationships between RTE and IHC features tumor stroma ratio, cell count, Ki67 proliferation index, and CD45 expression were evaluated using Spearman's rank correlation coefficients.ResultsSignificant differences in RTE were observed across different MRI phases among patients with BCLM, CRCLM, and PCLM: arterial phase (0.75 +/- 0.42, 0.37 +/- 0.36, and 0.44 +/- 0.19), portal venous phase (1.09 +/- 0.41, 0.59 +/- 0.44, and 0.53 +/- 0.24), and venous phase (1.11 +/- 0.45, 0.65 +/- 0.61, and 0.50 +/- 0.20). In CRCLM, RTE inversely correlated with mean Ki67 (r = -0.50, p = 0.01) in the hepatobiliary phase. Negative correlations between RTE and CD45 expression were found in PCLM and CRCLM in the portal venous phase (r = -0.69, p = 0.01 and r = -0.41, p = 0.04) and the venous phase (r = -0.65, p = 0.01 and r = -0.44, p = 0.02).ConclusionSignificant variations in RTE were identified among different types of LM, with correlations between RTE values and IHC markers such as CD45 and Ki67 suggesting that RTE may serve as a non-invasive biomarker for predicting IHC features in LM.Critical relevance statementRTE values serve as a predictive biomarker for IHC features in liver metastasis, potentially enhancing non-invasive patient assessment, disease monitoring, and treatment planning.Key PointsFew studies link gadoxetic acid-enhanced MRI with immunohistochemistry in LM.RTE varies by liver metastasis type and correlates with CD45 and Ki67.RTE reflects IHC features in LM, aiding non-invasive assessment.
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页数:10
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