The task of scheduling jobs to machines while minimizing the total makespan, the sum of weighted completion times, or a norm of the load vector are among the oldest and most fundamental tasks in combinatorial optimization. Since all of these problems are in general NP-hard, much attention has been given to the regime where there is only a small number k of job types, but possibly the number of jobs n is large; this is the few job types, high-multiplicity regime. Despite many positive results, the hardness boundary of this regime was not understood until now. We show that makespan minimization on uniformly related machines (Q|HM|Cmax\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$Q|HM|C_{\max }$$\end{document}) is NP-hard already with 6 job types, and that the related Cutting Stock problem is NP-hard already with 8 item types. For the more general unrelated machines model (R|HM|Cmax\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$R|HM|C_{\max }$$\end{document}), we show that if the largest job size pmax\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$p_{\max }$$\end{document} or the number of jobs n is polynomially bounded in the instance size |I|, there are algorithms with complexity |I|poly(k)\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$|I|<^>{{{\,\mathrm{\textrm{poly}}\,}}(k)}$$\end{document}. Our main result is that this is unlikely to be improved because Q||Cmax\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$Q||C_{\max }$$\end{document} is W[1]\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\mathsf {W[1]}$$\end{document}-hard parameterized by k already when n, pmax\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$p_{\max }$$\end{document}, and the numbers describing the machine speeds are polynomial in |I|; the same holds for R||Cmax\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$R||C_{\max }$$\end{document} (without machine speeds) when the job sizes matrix has rank 2. Our positive and negative results also extend to the objectives & ell;2\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\ell _2$$\end{document}-norm minimization of the load vector and, partially, sum of weighted completion times & sum;wjCj\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\sum w_j C_j$$\end{document}. Along the way, we answer affirmatively the question whether makespan minimization on identical machines (P||Cmax\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$P||C_{\max }$$\end{document}) is fixed-parameter tractable parameterized by k, extending our understanding of this fundamental problem. Together with our hardness results for Q||Cmax\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$Q||C_{\max }$$\end{document}, this implies that the complexity of P|HM|Cmax\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$P|HM|C_{\max }$$\end{document} is the only remaining open case.
