Amine-Promoted Three-Component Radical Selenofunctionalization for the Construction of β-Hydroxy Selenide Derivatives

被引：0
|
作者：
Zhang, Jiantao [1 ,2 ]
Su, Renhua [1 ]
Zhou, Peng [1 ]
Chen, Cui [1 ]
Liu, Weibing [1 ]
机构：
[1] Guangdong Univ Petrochem Technol, Coll Chem, Maoming 525000, Peoples R China
[2] Maoming Green Chem Ind Res Inst, Maoming 525099, Guangdong, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 90卷 / 01期
基金：
中国国家自然科学基金;
关键词：
ALKENES; OLEFINS; DISELENIDES; OXIDANT; ACCESS;
D O I：
10.1021/acs.joc.4c02149
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An amine-promoted three-component radical selenofunctionalization reaction of alkenes with TBHP and diselenide is disclosed. The reaction conditions are mild and suitable for a wide range of substrates (29 examples), and all give the corresponding hydroxyselenenylation products in moderate to excellent yields. In addition, preliminary studies on the mechanism reveal that the current method might proceed via a radical pathway. TBHP serves as both radical initiator and the source of hydroxyl group.
引用
收藏
页码：217 / 224
页数：8
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