Function and regulation of protein neddylation

被引:0
|
作者
Gwénaël Rabut [1 ]
Matthias Peter [1 ]
机构
[1] Swiss Federal Institute of Technology Zürich (ETH),
[2] Institute of Biochemistry,undefined
来源
The EMBO Reports | 2008年 / 9卷 / 10期
关键词
cullin; NEDD8; neddylation; Rub1;
D O I
10.1038/embor.2008.183
中图分类号
学科分类号
摘要
Neddylation is the post‐translational protein modification that is most closely related to ubiquitination. However, ubiquitination is known to regulate a myriad of processes in eukaryotic cells, whereas only a limited number of neddylation substrates have been described to date. Here, we review the principles of protein neddylation and highlight the mechanisms that ensure the specificity of neddylation over ubiquitination. As numerous neddylation substrates probably remain to be discovered, we propose some criteria that could be used as guidelines for the characterization of neddylated proteins.
引用
收藏
页码:969 / 976
页数:7
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