Synthesis, Characterization, and Biological Activity of 1-(Pyridin-4-yl)-1H-pyrazol-5-amine Derivatives

被引：0
|
作者：
Rechel, P. A. [1 ]
Jyothi, S. [1 ]
机构：
[1] Kakatiya Univ, Dept Chem, Warangal 506001, Telangana, India
来源：
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 60卷 / 12期
关键词：
pyrazole; pyrazol-5-amine; antimicrobial activity; spectral characterization; PYRAZOLE DERIVATIVES;
D O I：
10.1134/S1070428024120157
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
2-Chloro-N-[3-methyl-1-(pyridin-4-yl)-1H-pyrazol-5-yl]acetamide (2) was synthesized from 3-methyl-1-(pyridin-4-yl)-1H-pyrazol-5-amine (1) and chloroacetyl chloride in DMF under reflux condition in a straightforward and very efficient process. New pyrazole derivatives were synthesized from compounds 1 and 2 and were characterized by elemental analysis, IR, H-1 NMR, C-13 NMR, and mass spectroscopy. The antimicrobial activity of the synthesized compounds was evaluated against a variety of bacterial and fungal species in comparison to streptomycin and nystatin, respectively.
引用
收藏
页码：2417 / 2421
页数：5
相关论文
共 50 条
  • [41] Synthesis and biological evaluation of 1-(5-(2-chloroquinolin-3-yl)-3-phenyl-1H-pyrazol-1-yl)ethanone derivatives as potential antimicrobial agents
    Miniyar, Pankaj B.
    Barmade, Mahesh A.
    Mahajan, Anand A.
    JOURNAL OF SAUDI CHEMICAL SOCIETY, 2015, 19 (06) : 655 - 660
  • [42] Synthesis and biological evaluation of 1-(4-(piperazin-1-yl)phenyl) pyridin-2(1H)-one derivatives as potential SSRIs
    Xu, Tengfei
    Xue, Yaping
    Lu, Jielian
    Jin, Chuanfei
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 223
  • [43] The new 3-(tert-butyl)-1-(2-nitropheny1)-1H-pyrazol-5-amine: Experimental and computational studies
    Cuenu, Fernando
    Munoz-Patino, Natalia
    Eduard Torres, John
    Abonia, Rodrigo
    Toscano, Ruben A.
    Cobo, J.
    JOURNAL OF MOLECULAR STRUCTURE, 2017, 1148 : 557 - 567
  • [44] Glutaric acid-2-(pyridin-4-yl)-1H-benzimidazole (1/1)
    Lin, Songzhu
    Jia, Ruokun
    He, Aimin
    Gao, Xiaoli
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2011, 67 : O3463 - U1350
  • [45] 3-Methyl-1-phenyl-N-(2-thienylmethylene)-1H-pyrazol-5-amine
    Yang, Fang
    Li, Xiao-Yue
    Wang, Hai-Ying
    Ni, Sai-Nan
    Shi, Da-Qing
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2006, 62 : O3566 - O3567
  • [46] Synthesis, Characterization, Biological, and Molecular Docking Studies of (Z)-N-Substituted-4-(Pyridin-2-yl)-6-(1H-Pyrrolo[2,3-b]Pyridin-4-yl)Pyrimidin-2-Amine
    M. Arshad
    M. S. Akhter
    Russian Journal of Bioorganic Chemistry, 2022, 48 : 1068 - 1075
  • [47] Development of a Novel Chemoenzymatic Process for (S)-1-(Pyridin-4-yl)-1,3-propanediol
    Wang, Hong-Yi
    Tang, Jia-Wei
    Peng, Peng
    Yan, Hai-Jun
    Zhang, Fu-Li
    Chen, Shao-Xin
    ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2020, 24 (12) : 2890 - 2897
  • [48] Synthesis and biological evaluation of 1,2,3-triazole incorporated pyridin-4-yl)-1H-1,2,4-triazol-3-yl)pyrimidine derivatives as anticancer agents
    Reddy, B. Siva
    Rao, G. Purna Chandra
    Devi, E. Ramya
    Prasad, K. R. S.
    Nalla, Somaiah
    RESULTS IN CHEMISTRY, 2024, 8
  • [49] Synthesis, Characterization, Biological, and Molecular Docking Studies of (Z)-N-Substituted-4-(Pyridin-2-yl)-6-(1H-Pyrrolo[2,3-b]Pyridin-4-yl)Pyrimidin-2-Amine
    Arshad, M.
    Akhter, M. S.
    RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY, 2022, 48 (05) : 1068 - 1075
  • [50] Design and synthesis of novel 3-(benzo[d]oxazol-2-yl)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine derivatives as selective G-protein-coupled receptor kinase-2 and -5 inhibitors
    Cho, Sung Yun
    Lee, Byung Ho
    Jung, Heejung
    Yun, Chang Soo
    Du Ha, Jae
    Kim, Hyoung Rae
    Chae, Chong Hak
    Lee, Jeong Hyun
    Seo, Ho Won
    Oh, Kwang-Seok
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2013, 23 (24) : 6711 - 6716
12345