Synthesis, Characterization, and Biological Activity of 1-(Pyridin-4-yl)-1H-pyrazol-5-amine Derivatives

被引：0
|
作者：
Rechel, P. A. [1 ]
Jyothi, S. [1 ]
机构：
[1] Kakatiya Univ, Dept Chem, Warangal 506001, Telangana, India
来源：
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 60卷 / 12期
关键词：
pyrazole; pyrazol-5-amine; antimicrobial activity; spectral characterization; PYRAZOLE DERIVATIVES;
D O I：
10.1134/S1070428024120157
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
2-Chloro-N-[3-methyl-1-(pyridin-4-yl)-1H-pyrazol-5-yl]acetamide (2) was synthesized from 3-methyl-1-(pyridin-4-yl)-1H-pyrazol-5-amine (1) and chloroacetyl chloride in DMF under reflux condition in a straightforward and very efficient process. New pyrazole derivatives were synthesized from compounds 1 and 2 and were characterized by elemental analysis, IR, H-1 NMR, C-13 NMR, and mass spectroscopy. The antimicrobial activity of the synthesized compounds was evaluated against a variety of bacterial and fungal species in comparison to streptomycin and nystatin, respectively.
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收藏
页码：2417 / 2421
页数：5
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