Complicated crosstalk between HMGA and non-coding RNAs modulates hallmarks of cancer

被引：0
|
作者：
Zhang, Lijie [1 ]
Zhao, Xiaomin [1 ]
Gao, Xianghong [1 ]
Qin, Hao [1 ]
Chen, Feng [2 ]
Lin, Zhijuan [1 ]
机构：
[1] Shandong Second Med Univ, Key Lab Immunol Univ Shandong Prov, Sch Basic Med Sci, Weifang 261053, Shandong, Peoples R China
[2] Shandong Second Med Univ, Weifang Hosp Tradit Chinese Med, Weifang 261001, Shandong, Peoples R China
来源：
CANCER CELL INTERNATIONAL | 2025年 / 25卷 / 01期
基金：
中国国家自然科学基金;
关键词：
LncRNA; CircRNA; HMGA1; Tumorigenesis; Targeted therapy; RENAL-CELL CARCINOMA; AT-HOOK; TARGETING HMGA1; GASTRIC-CANCER; INHIBITS PROLIFERATION; ENDOMETRIAL CARCINOMA; MALIGNANT PHENOTYPE; OSTEOSARCOMA CELLS; MIGRATION; EXPRESSION;
D O I：
10.1186/s12935-025-03713-1
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
High mobility group A1 (HMGA1) is a class of non-histone chromosomal protein and is highly expressed in the embryonic period and many tumors. It is involved in multiple hallmarks of tumors and affects the occurrence and progression of tumors. Nowadays, many non-coding RNAs (ncRNAs), such as miRNA, lncRNA, and circRNA, have been found to play a crucial role in HMGA1 regulation. Moreover, some ncRNAs are reported to be the downstream effectors of HMGA1. They interact with each other to affect multiple hallmarks of cancer and targeting ncRNAs or HMGA1 may provide potential strategies for cancer therapy. In this review, we give an overview of recent studies describing the crosstalk between oncogenic HMGA1 and ncRNAs. We also point out the impact of this interaction on the biological behavior of tumors and their potential in tumor therapy in order to offer potential implications and directions for both basic science and clinical applications.
引用
收藏
页数：13
相关论文
共 50 条
  • [41] Long non-coding RNAs in cancer
    GONG ZhaoJian ZHANG ShanShan ZHANG WenLing HUANG HongBin LI Qiao DENG Hao MA Jian ZHOU Ming XIANG JuanJuan WU MingHua LI XiaYu XIONG Wei LI XiaoLing LI Yong ZENG ZhaoYang LI GuiYuan Hunan Key Laboratory of Nonresolving Inflammation and Cancer Disease Genome Research Center the Third Xiangya Hospital Central South University Changsha China Key Laboratory of Carcinogenesis of Ministry of Health Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education Cancer Research Institute Central South University Changsha China Department of Stomatology the Second Xiangya Hospital Central South University Changsha China Department of Stomatology Xiangya Hospital Central South University Changsha China Key Laboratory of Information System Engineering National University of Defense Technology Changsha China Department of Biochemistry and Molecular Biology Center for Genetics and Molecular Medicine School of Medicine University of Louisville Louisville KY USA
    Science China(Life Sciences), 2012, 55 (12) : 1120 - 1124
  • [42] Non-coding RNAs in gynecologic cancer
    Solati, Arezoo
    Thvimi, Sina
    Khatami, Seyyed Hossein
    Shabaninejad, Zahra
    Malekzadegan, Yalda
    Alizadeh, Mehdi
    Mousavi, Pegah
    Taheri-Anganeh, Mortaza
    Razmjoue, Damoun
    Bahmyari, Sedigheh
    Ghasemnejad-Berenji, Hojat
    Vafadar, Asma
    Fard, Elahe Soltani
    Ghasemi, Hassan
    Movahedpour, Ahmad
    CLINICA CHIMICA ACTA, 2023, 551
  • [43] Non-coding RNAs and gastric cancer
    Li, Pei-Fei
    Chen, Sheng-Can
    Xia, Tian
    Jiang, Xiao-Ming
    Shao, Yong-Fu
    Xiao, Bing-Xiu
    Guo, Jun-Ming
    WORLD JOURNAL OF GASTROENTEROLOGY, 2014, 20 (18) : 5411 - 5419
  • [44] Non-coding RNAs in gastric cancer
    Xie, Shanshan
    Chang, Yongxia
    Jin, Hao
    Yang, Feng
    Xu, Yanjun
    Yan, Xiaoyi
    Lin, Aifu
    Shu, Qiang
    Zhou, Tianhua
    CANCER LETTERS, 2020, 493 : 55 - 70
  • [45] Non-Coding RNAs in Thyroid Cancer
    Ranran Zhang
    Heather Hardin
    Jidong Chen
    Zhenying Guo
    Ricardo V. Lloyd
    Endocrine Pathology, 2016, 27 : 12 - 20
  • [46] Non-coding RNAs in gastric cancer
    Wang, Jun
    Song, Yong-Xi
    Wang, Zhen-Ning
    GENE, 2015, 560 (01) : 1 - 8
  • [47] Non-coding RNAs and gastric cancer
    Pei-Fei Li
    Sheng-Can Chen
    Tian Xia
    Xiao-Ming Jiang
    Yong-Fu Shao
    Bing-Xiu Xiao
    Jun-Ming Guo
    World Journal of Gastroenterology, 2014, (18) : 5411 - 5419
  • [48] Roles of non-coding RNAs in intercellular crosstalk in cardiovascular diseases
    Lim, Yeong-Hwan
    Kim, Young-Kook
    KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, 2023, 27 (04): : 289 - 298
  • [49] Alzheimer's disease and microorganisms: the non-coding RNAs crosstalk
    Mohammadi-Pilehdarboni, Hanieh
    Shenagari, Mohammad
    Joukar, Farahnaz
    Naziri, Hamed
    Mansour-Ghanaei, Fariborz
    FRONTIERS IN CELLULAR NEUROSCIENCE, 2024, 17
  • [50] Crosstalk between the Notch signaling pathway and non-coding RNAs in gastrointestinal cancers (Review)
    Pan, Yangyang
    Mao, Yuyan
    Jin, Rong
    Jiang, Lei
    ONCOLOGY LETTERS, 2018, 15 (01) : 31 - 40
12345