Purpose of Review Pharmacologic alternatives in management of obstructive sleep apnea (OSA) have been pursued for decades. Considering rapid development and promising findings in recent years, we provide an overview of novel agents and treatment targets, ongoing trials, as well as future perspectives.Recent Findings Several drugs demonstrate efficacy, though none is sufficient to cure the disease as a monotherapy. Instead, the main potential lies in applying drug therapy in specific subgroups or as an addition to established treatments (e.g., positive airway pressure, oral appliance therapy). Glucagon-like peptide-1 (GLP-1)/glucose-dependent insulinotropic polypeptide (GIP) receptor agonists may be particularly beneficial in obese OSA patients. As a major breakthrough, terzipatide, a GIP analog and GLP-1 receptor agonist, has become the first FDA-approved and EMA-sanctioned pharmacologic treatment option of OSA in obese individuals. Beyond this, alerting drugs could help manage residual daytime sleepiness and improve daytime functioning. However, long-term studies on safety, adherence, and effectiveness are scarce and highlight certain limitations and challenges.Summary Incorporating pharmaceuticals along conventional OSA management may provide synergy benefit in certain patients, but side-effects and risk reduction of related adverse outcomes over time is yet to be assessed. Furthermore, guidelines/frameworks for mapping out applicable treatment targets are needed.
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Case Western Reserve Univ, Cleveland, OH USACase Western Reserve Univ, Cleveland, OH USA
Strohl, Kingman
Mehra, Reena
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Cleveland Clin, Neurol Inst, Sleep Disorders Ctr, Cleveland, OH USACase Western Reserve Univ, Cleveland, OH USA
Mehra, Reena
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Patel, Sanjay
Pena-Orbea, Ciythya
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Cleveland Clin Fdn, Cleveland, OH USACase Western Reserve Univ, Cleveland, OH USA
Pena-Orbea, Ciythya
Bogan, Richard
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Univ South Carolina, Sch Med, Columbia, SC USA
Med Univ South Carolina, Charleston, SC USA
Bogan Sleep Consultants LLC, Columbia, SC USACase Western Reserve Univ, Cleveland, OH USA
Bogan, Richard
Magalang, Ulysses
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Ohio State Univ, Med Ctr, Columbus, OH USACase Western Reserve Univ, Cleveland, OH USA
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Repatriat Gen Hosp, Adelaide Inst Sleep Hlth, Adelaide, SA 5041, Australia
Univ Adelaide, Sch Med Sci, Discipline Physiol, Adelaide, SA, AustraliaRepatriat Gen Hosp, Adelaide Inst Sleep Hlth, Adelaide, SA 5041, Australia
Vakulin, Andrew
Baulk, Stuart D.
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Kent Town, Integrated Safety Support, Adelaide, SA, AustraliaRepatriat Gen Hosp, Adelaide Inst Sleep Hlth, Adelaide, SA 5041, Australia
Baulk, Stuart D.
Catcheside, Peter G.
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Repatriat Gen Hosp, Adelaide Inst Sleep Hlth, Adelaide, SA 5041, Australia
Univ Adelaide, Sch Med Sci, Discipline Physiol, Adelaide, SA, Australia
Flinders Univ S Australia, Dept Med, Bedford Pk, SA 5042, AustraliaRepatriat Gen Hosp, Adelaide Inst Sleep Hlth, Adelaide, SA 5041, Australia
Catcheside, Peter G.
Antic, Nick A.
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Repatriat Gen Hosp, Adelaide Inst Sleep Hlth, Adelaide, SA 5041, Australia
Flinders Univ S Australia, Dept Med, Bedford Pk, SA 5042, AustraliaRepatriat Gen Hosp, Adelaide Inst Sleep Hlth, Adelaide, SA 5041, Australia
Antic, Nick A.
van den Heuvel, Cameron J.
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Univ Adelaide, Womens & Childrens Hosp, Childrens Res Ctr, Adelaide, SA, AustraliaRepatriat Gen Hosp, Adelaide Inst Sleep Hlth, Adelaide, SA 5041, Australia
van den Heuvel, Cameron J.
Dorrian, Jillian
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Univ S Australia, Ctr Sleep Res, Sch Psychol Social Work & Social Policy, Adelaide, SA 5001, AustraliaRepatriat Gen Hosp, Adelaide Inst Sleep Hlth, Adelaide, SA 5041, Australia
Dorrian, Jillian
McEvoy, R. Doug
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Repatriat Gen Hosp, Adelaide Inst Sleep Hlth, Adelaide, SA 5041, Australia
Univ Adelaide, Sch Med Sci, Discipline Physiol, Adelaide, SA, Australia
Flinders Univ S Australia, Dept Med, Bedford Pk, SA 5042, AustraliaRepatriat Gen Hosp, Adelaide Inst Sleep Hlth, Adelaide, SA 5041, Australia
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S Luca Hosp, Fdn Don C Gnocchi, IRCCS, Ist Auxol Italiano, I-20148 Milan, ItalyS Luca Hosp, Fdn Don C Gnocchi, IRCCS, Ist Auxol Italiano, I-20148 Milan, Italy
Castiglioni, P.
Lombardi, C.
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S Luca Hosp, Dept Cardiol, IRCCS, Ctr Sleep Disorders,Ist Auxol Italiano, I-20148 Milan, ItalyS Luca Hosp, Fdn Don C Gnocchi, IRCCS, Ist Auxol Italiano, I-20148 Milan, Italy