A New Naphtho[2,3-c]Furan-1(3H)-One Derivative and Anti-Inflammatory and Antioxidant Constituents from Rhamnus kanagusukii

被引：0
|
作者：
Kuo, Chu-Wen [1 ]
Chen, Zih-Rong [2 ]
Huang, Hsueh-Yang [1 ]
Liaw, Chia-Ching [3 ]
Sung, Ping-Jyun [4 ]
Cheng, Ming-Jen [5 ]
Wu, Fu-Sen [6 ]
Chen, Jih-Jung [2 ,7 ,8 ]
机构：
[1] Kaohsiung Armed Forces Gen Hosp, Dept Pharm, Kaohsiung 802301, Taiwan
[2] Natl Yang Ming Chiao Tung Univ, Sch Pharmaceut Sci, Dept Pharm, Taipei 112304, Taiwan
[3] Natl Res Inst Chinese Med, Div Chinese Mat Med Dev, Taipei 112304, Taiwan
[4] Natl Museum Marine Biol & Aquarium, Pingtung 944401, Taiwan
[5] Fu Jen Catholic Univ, Dept Life Sci, New Taipei City 242062, Taiwan
[6] Far Eastern Mem Hosp, Dept Pharm, New Taipei City 220216, Taiwan
[7] China Med Univ, China Med Univ Hosp, Dept Med Res, Taichung 404327, Taiwan
[8] Taipei Med Univ Hosp, Tradit Herbal Med Res Ctr, Taipei 110301, Taiwan
来源：
CHEMISTRY OF NATURAL COMPOUNDS | 2025年 / 61卷 / 01期
关键词：
Rhamnus kanagusukii; Rhamnaceae; stem bark; naphtho[2,3-c]furan-1(3H)-one; anti-inflammatory activity; FRUITS; BARK;
D O I：
10.1007/s10600-025-04581-x
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A new naphtho[2,3-c]furan-1(3H)-one derivative, 6,8,9-trihydroxynaphtho[2,3-c]furan-1(3H)-one (1), has been isolated from the stem bark of Rhamnus kanagusukii, together with eight known compounds, chrysophanol (2), emodin (3), rhamnazin (4), kaempferol (5), apigenin (6), taxifolin (7), ferulic acid (8), and gallic acid (9). The structure of new compound 1 was determined using spectroscopic and MS analyses. Among the isolated compounds, 6,8,9-trihydroxynaphtho[2,3-c]furan-1(3H)-one (1), kaempferol (5), apigenin (6), and taxifolin (7) showed potent inhibition with IC50 values of 19.48 +/- 1.52, 20.48 +/- 1.84, 16.47 +/- 1.25, and 15.44 +/- 1.02 mu M, respectively, against LPS-induced NO generation. In addition, compounds 5, 6, 7, 8, and 9 also showed potent DPPH radical scavenging activities with IC50 values of 21.11 +/- 1.84, 22.47 +/- 2.04, 13.02 +/- 1.07, 14.54 +/- 1.35, and 13.48 +/- 1.16 mu M respectively.
引用
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页码：86 / 90
页数：5
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