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Research progress on the signaling pathway mechanism of terpenoids against breast cancer
被引:0
|作者:
Tu, Sheng-nan
[1
]
Hu, Fen
[2
]
Zhang, Juan
[3
]
Cai, Haifeng
[3
]
Yang, Junquan
[1
]
机构:
[1] North China Univ Sci & Technol, Sch Clin Med, Tangshan 063210, Peoples R China
[2] North China Univ Sci & Technol, Coll Life Sci, Tangshan 063210, Peoples R China
[3] Tangshan Peoples Hosp, Dept Mammary Gland 2, Tangshan 063000, Peoples R China
关键词:
Breast cancer;
Terpenoids;
Signal passage;
Review;
CELL-CYCLE ARREST;
OXIDATIVE STRESS;
APOPTOSIS;
LYCOPENE;
GROWTH;
INVASIVENESS;
COMBINATION;
INVOLVEMENT;
METASTASIS;
INHIBITION;
D O I:
10.1007/s12672-025-01881-0
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
Breast cancer is the most common malignant tumor in women worldwide. Current treatments include chemotherapy, hormone therapy, radiotherapy and surgery. Terpenoids have great anti-cancer potential due to their anti-inflammatory, antioxidant, anti-tumor, antiviral and other biological activities. They have become the central drug for the prevention and treatment of breast cancer. However, their low bioavailability and stability are urgent issues that need to be addressed. This article aims to sort out the mechanism of action of terpenoids in the treatment of breast cancer. By reviewing different signal transduction pathways, it is hoped that new ideas for the joint action of multiple pathways and multiple targets will be provided, and a theoretical basis will be provided for improving basic research and clinical treatment of breast cancer.
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页数:18
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