Effect of XBB.1.5-adapted booster vaccination on the imprinting of SARS-CoV-2 immunity

被引：1
|
作者：
Pusnik, Jernej [1 ,2 ]
Monzon-Posadas, Werner O. [1 ,2 ,3 ]
Osypchuk, Emmanuil [1 ,2 ]
Dubiel, Aleksandra Elzbieta [1 ,2 ]
Baum, Maximilian [1 ,2 ]
Fehring, Paulina [1 ,2 ]
Buening, Antonia [1 ,2 ]
Klant, Tobias [1 ]
Streeck, Hendrik [1 ,2 ]
机构：
[1] Univ Hosp Bonn, Inst Virol, D-53127 Bonn, Germany
[2] German Ctr Infect Res DZ, Partner site Bonn Cologne, D-53127 Bonn, Germany
[3] Univ Hosp Bonn, Occupat Med Dept, D-53127 Bonn, Germany
来源：
NPJ VACCINES | 2024年 / 9卷 / 01期
关键词：
VIRUS;
D O I：
10.1038/s41541-024-01023-7
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
In the present study, Pu & scaron;nik et al. investigated whether the XBB.1.5-adapted booster can overcome the persistent imprinting of SARS-CoV-2 immunity by wild-type based vaccines. The findings demonstrate increased plasma neutralization against the homologous variant following the booster vaccination. Formation of de novo humoral response against the mutated epitopes of XBB.1.5 variant's surface proteins was observed in 3/20 individuals. The booster vaccination had no significant effect on T-cell response.
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页数：5
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