Design, Synthesis, and Anticancer Activities of Bakuchiol-1,3,5-triazine Derivatives

被引：0
|
作者：
Li, Rui [1 ]
Ding, Ya-Min [1 ]
Qin, Tian [2 ]
Xue, Xuan-Yi [1 ]
Liu, Wei-Wei [1 ]
Wei, Rong-Bin [1 ]
Zhai, Yuan-Fen [1 ]
Ding, Gang [2 ]
Shi, Da-Hua [1 ]
机构：
[1] Jiangsu Ocean Univ, Co Innovat Ctr Jiangsu Marine Bioind Technol, Sch Pharm, Jiangsu Key Lab Marine Bioresources & Environm, Lianyungang 222005, Peoples R China
[2] Chinese Acad Med Sci & Peking Union Med Coll, Inst Med Plant Dev, Key Lab Bioact Subst & Resources Utilizat Chinese, Minist Educ, Beijing 100193, Peoples R China
来源：
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY | 2024年 / 50卷 / 05期
关键词：
bakuchiol; 1,3,5-triazine; antitumor activity; Panc-1; BAKUCHIOL DERIVATIVES; 2,4,6-TRICHLORO-1,3,5-TRIAZINE;
D O I：
10.1134/S1068162024050066
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Objective: In search of the better anticancer agents, fifteen bakuchiol-1,3,5-triazine derivatives were designed and synthesized through nucleophilic substitution reaction. Methods: The newly synthesized derivatives were evaluated for their in vitro cytotoxic activity against Panc-1, MDA-MB-231, A549, and UM-UC-3 using the MTT assay. Results and Discussion: The data revealed that all of the bakuchiol-1,3,5-triazine derivatives could inhibit the proliferation of Panc-1 cells. Four compounds exhibited better antiproliferative activities than that of bakuchiol. Among them, compound (IVj) displayed potent antiproliferative activity with IC50 values of 21.83 mu M. Compound (IVj) also showed potent inhibitory activity against the proliferation of MDA-MB-231, A549, and UM-UC-3 cells when compared with bakuchiol. Additionally, compound (IVj) exhibited strong inhibitory effects on the migration, invasion, and adhesion of Panc-1 cells. Conclusions: The results showed that, compound (IVj) could be a promising candidate agent for the treatment of cancer.
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页码：1851 / 1862
页数：12
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