A Review of Analytical Methods for Quantification of Amphotericin-B in Marketed Dosage form and Biological Samples

被引：0

作者：

Bhagyasri, Chappa ^{[1
]}

Gollu, Gowri ^{[2
]}

Godela, Ramreddy ^{[3
]}

机构：

[1] Maharajahs Coll Pharm, Dept Pharmaceut Anal, Vizianagaram 535002, Andhra Pradesh, India

[2] Raghu Coll Pharm, Dept Pharmaceut Anal, Visakhapatnam 531162, Andhra Pradesh, India

[3] GITAM, GITAM Sch Pharm, Dept Pharmaceut Anal, Hyderabad 502329, Telangana, India

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2024年 / 58卷 / 08期

关键词：

PURITY; SERUM;

D O I：

10.1007/s11094-024-03281-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Amphotericin-B is an antifungal antibiotic indicated to treat infections caused by by leishmaniasis. After the COVID-19 outbreak, amphotericin-B was preferably used to treat black fungus caused by mucormycosis in people recovering from COVID-19. To test purity, identity and quantity of amphotericin-B in dosage forms and biological samples always needs different analytical methods such as spectroscopic, chromatographic, electro analytical methods and micro biological assays. This review depicts several analytical methods, along with instrumental conditions for the detection and quantification of amphotericin-B, that have been published over the last 20 years. HPLC with UV detection is predominantly used for quantification of amphotericin-B in pharmaceutical formulations and LC-MS is used in biological samples.

引用

页码：1353 / 1359

页数：7

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