Circular RNAs in the pathogenesis of SARS-CoV-2: potential diagnostic biomarkers and therapeutic targets

被引：0

作者：

Wu, Jiajie ^{[1
]}

Li, Lele ^{[1
]}

Xu, Wei ^{[1
]}

Xia, Xiaoping ^{[1
]}

Wu, Yingping ^{[1
]}

机构：

[1] Zhejiang Univ, Affiliated Hosp 4, Int Inst Med, Dept Clin Lab,Sch Med, Yiwu, Peoples R China

来源：

FUNCTIONAL & INTEGRATIVE GENOMICS | 2025年 / 25卷 / 01期

关键词：

Circular RNAs; SARS-CoV-2; Non-coding RNA; Virus-host interaction; RNA treatment; MERS-COV; NASOPHARYNGEAL CARCINOMA; CYTOKINE STORM; EXPRESSION; REPLICATION; COVID-19; CIRCRNAS; IDENTIFICATION; PROLIFERATION; PROFILE;

D O I：

10.1007/s10142-024-01509-6

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Since December 2019, the global dissemination of a novel coronavirus has precipitated a notable public health crisis, prompting considerable interest and scrutiny from governmental and scholarly entities. Substantial research efforts have been dedicated to exploring diverse facets of this novel coronavirus, encompassing its pathogenesis, transmission dynamics, and therapeutic interventions. Recent findings suggest that circular RNAs (circRNAs) exert a pivotal influence on modulating viral infectivity and immune defense mechanisms. The detection of differentially expressed circRNAs in individuals afflicted with SARS-CoV-2 signifies a noteworthy advancement in understanding the molecular mechanisms underpinning viral pathogenesis.

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页数：14

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