Dual orexin receptor antagonists as promising therapeutics for Alzheimer’s disease

被引：0

作者：

S. M. Ragsdale ^{[1
]}

J. M. Radovich ^{[2
]}

I. I. Coiduras ^{[3
]}

W. V. McCall ^{[1
]}

S. C. Grant ^{[4
]}

C. Lee ^{[2
]}

A. Wilber ^{[3
]}

机构：

[1] Department of Psychology; Program in Neuroscience; Florida State University,Department of Chemical & Biochemical Engineering, FAMU

[2] Florida State University,FSU College of Engineering

[3] Florida State University,CIMAR, National High Magnetic Field Laboratory

[4] Department of Psychiatry and Health Behavior; Medical College of Georgia; Augusta University,Department of Biomedical Sciences; Program in Neuroscience; College of Medicine

[5] Florida State University,undefined

来源：

npj Biological Timing and Sleep | / 2卷 / 1期

关键词：

D O I：

10.1038/s44323-025-00025-5

中图分类号：

学科分类号：

摘要：

We examine the relationship between sleep, glymphatics and Alzheimer’s disease (AD), and recent work questioning glymphatic clearance during sleep. We highlight a need for understanding glymphatic and/or other mechanism of clearance during sleep, and review glymphatic flow measurement methods. Further, we explore dual orexin receptor antagonists (DORAs) potential to mitigate AD sleep disturbances and enhance clearance. Further research could elucidate a linkage between DORAs, improved sleep and reducing AD pathophysiology.

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