Synthesis of Ethyl-2-Amino-1-(hetarylamido)-4-oxo-5-(2-oxo-2-phenylethylidene)-4,5-Dihydro-1H-Pyrrole-3-Carboxylates, the Study of their Antioxidant Activity, and the Ouantum Chemical Estimation of their Electronic Parameters

被引：0
|
作者：
Ilyina, M. G. [1 ]
Shustov, M. V. [2 ]
Igidov, N. M. [2 ]
Khamitov, E. M. [1 ]
Borisevich, S. S. [1 ]
Zykova, S. S. [2 ]
机构：
[1] Russian Acad Sci, Ufa Inst Chem, Ufa Fed Res Ctr, Ufa, Russia
[2] Minist Hlth Russian Federat, Perm State Pharmaceut Acad, Perm, Russia
来源：
JOURNAL OF STRUCTURAL CHEMISTRY | 2024年 / 65卷 / 12期
关键词：
HIF-1; alpha; DPPH test; antioxidants; quantum chemical calculations; conformational analysis; TUMOR-GROWTH; 2-METHOXYESTRADIOL; ANGIOGENESIS; HYPOXIA;
D O I：
10.1134/S0022476624120011
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Ethyl-2-amino-1-(hetarylamido)-4-oxo-5-(2-oxo-2-phenylethylidene)-4,5-dihydro-1H-pyrrole-3-carboxylates are synthesized, their antiradical and antioxidant activities are studied, and the quantum chemical calculations are performed. The nitrogen atom position in the pyridine moiety of the derivatives is found to change the toxicity of synthesized compounds and to affect the ability to bind free radicals. The results can facilitate the further determination of the structure - activity relationship in the considered types of the biological activity.
引用
收藏
页码：2359 / 2370
页数：12
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