Sensitivity of rodents to SARS-CoV-2: Gerbils are susceptible to SARS-CoV-2, but guinea pigs are not

被引：0

作者：

Kiyoko Iwatsuki-Horimoto ^{[1
]}

Maki Kiso ^{[2
]}

Mutsumi Ito ^{[1
]}

Seiya Yamayoshi ^{[2
]}

Yoshihiro Kawaoka ^{[1
]}

机构：

[1] University of Tokyo,Division of Virology, Institute of Medical Science

[2] University of Tokyo,The University of Tokyo Pandemic Preparedness, Infection and Advanced Research Center (UTOPIA)

[3] National Center for Global Health and Medicine Research Institute,The Research Center for Global Viral Diseases

[4] University of Tokyo,Department of Special Pathogens, International Research Center for Infectious Diseases, Institute of Medical Science

[5] University of Wisconsin-Madison,Department of Pathobiological Sciences, Influenza Research Institute, School of Veterinary Medicine

来源：

npj Viruses | / 2卷 / 1期

关键词：

D O I：

10.1038/s44298-024-00068-8

中图分类号：

学科分类号：

摘要：

Syrian hamster are sensitive to SARS-CoV-2 and widely used as an animal model of COVID-19. In contrast, mice are not readily infected by the ancestral strains of SARS-CoV-2 because of differences in their angiotensin-converting enzyme 2 (ACE2) receptors. Thus, even among rodents, susceptibility to SARS-CoV-2 varies. Knowledge of virus transmissibility from humans to pet rodents is important for public health to assess the potential for transmission in the home and pet breeding and selling facilities. In this study, we assessed the sensitivity of guinea pigs and gerbils to SARS-CoV-2 isolated from humans, and found that gerbils are susceptible to SARS-CoV-2, but guinea pigs are not. Pet sellers often display hamsters with high susceptibility to SARS-CoV-2 in the same area as gerbils, so caution should be exercised during COVID-19 outbreaks.

引用

共 50 条

[21] Risk of appendicitis after SARS-CoV-2 infection and SARS-CoV-2 vaccination
Ljung, Rickard
Pihlstrom, Nicklas
Sundstrom, Anders
BRITISH JOURNAL OF SURGERY, 2022, 109 (08) : 775 - 776
[22] Product of natural evolution (SARS, MERS, and SARS-CoV-2); deadly diseases, from SARS to SARS-CoV-2
Shahrajabian, Mohamad Hesam
Sun, Wenli
Cheng, Qi
HUMAN VACCINES & IMMUNOTHERAPEUTICS, 2021, 17 (01) : 62 - 83
[23] Serum SARS-COV-2 Nucleocapsid Protein: A Sensitivity and Specificity Early Diagnostic Marker for SARS-COV-2 Infection
Li, Tao
Wang, Li
Wang, Huihui
Li, Xuemei
Zhang, Shubing
Xu, Yuanhong
Wei, Wei
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 2020, 10
[24] SARS-CoV-2 and dentistry
Ortega, Karem L.
Rodrigues de Camargo, Alessandra
Bertoldi Franco, Juliana
Mano Azul, Antonio
Perez Sayans, Mario
Braz Silva, Paulo Henrique
CLINICAL ORAL INVESTIGATIONS, 2020, 24 (07) : 2541 - 2542
[25] Spread of SARS-CoV-2
Stower, Hannah
NATURE MEDICINE, 2020, 26 (04) : 465 - 465
[26] SARS-CoV-2 Vaccines
Creech, C. Buddy
Walker, Shannon C.
Samuels, Robert J.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2021, 325 (13): : 1318 - 1320
[27] SARS-CoV-2 in humans
Binder, Marco
Wyler, Emanuel
BERLINER UND MUNCHENER TIERARZTLICHE WOCHENSCHRIFT, 2021, 134
[28] Sequencing SARS-CoV-2
不详
BULLETIN OF THE WORLD HEALTH ORGANIZATION, 2021, 99 (02) : 79 - 79
[29] The origin of SARS-CoV-2
Burki, Talha
LANCET INFECTIOUS DISEASES, 2020, 20 (09): : 1018 - 1019
[30] The heart and SARS-CoV-2
Gonzalez-Calle, David
Eiros, Rocio
Sanchez, Pedro L.
MEDICINA CLINICA, 2022, 159 (09): : 440 - 446

← 1 2 3 4 5 →